1. Metabolic Enzyme/Protease
  2. Angiotensin-converting Enzyme (ACE)
  3. Zofenoprilat

Zofenoprilat 是口服有效的血管紧张素转换酶 (ACE) 抑制剂,IC50 为 1.7 nM。Zofenoprilat 抑制血管紧张素 II 的表达,降低血压,从而发挥心脏保护和肾脏保护作用。Zofenoprilat 促进 NO 生成,降低内皮素-1 (ET-1) 表达,对血管内皮功能具有保护作用。Zofenoprilat 调节氧化应激相关分子,具有抗氧化活性。

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Zofenoprilat Chemical Structure

Zofenoprilat Chemical Structure

CAS No. : 75176-37-3

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生物活性

Zofenoprilat is an orally active inhibitor for angiotensin converting enzyme (ACE) with an IC50 of 1.7 nM. Zofenoprilat inhibits the expression of angiotensin II, reduces the blood pressure, exhibits thus cardioprotective and renalprotective activity. Zofenoprilat promotes the NO production, decreases endothelin-1 (ET-1) expression, exhibits protective effect on vascular endothelial function. Zofenoprilat regulates oxidative stress-related molecules, exhibits antioxidant activity[1][2].

分子量

325.45

Formula

C15H19NO3S2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Zofenoprilat
目录号:
HY-133829
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