2. Apoptosis
  3. Apoptosis
  4. 3-​O-​Acetyloleanolic acid

3-​O-​Acetyloleanolic acid  (Synonyms: 齐墩果酸3-乙酸酯)

目录号: HY-N2618 纯度: 99.84%
COA 产品使用指南 技术支持

3-O-Acetyloleanolic acid (3AOA) 是从Vigna sinensis K. 种子中提取得到的一种齐墩果醇酸，可诱导癌细胞凋亡并拥有抗血管生成作用。

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3-​O-​Acetyloleanolic acid Chemical Structure

3-​O-​Acetyloleanolic acid Chemical Structure

CAS No. : 4339-72-4

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规格 价格 是否有货 数量
1 mg ￥350
In-stock
5 mg ￥850
In-stock
10 mg ￥1300
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

3-​O-​Acetyloleanolic acid 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

3-O-Acetyloleanolic acid (3AOA), an oleanolic acid derivative isolated from the seeds of Vigna sinensis K., induces in cancer and also exhibits anti-angiogenesis activity[1].

IC50 & Target

Apoptosis[1].
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
5.8 μM
Compound: 1
Antiproliferative activity against human A549 cells harbouring wild type EGFR incubated for 72 hrs by SRB assay
Antiproliferative activity against human A549 cells harbouring wild type EGFR incubated for 72 hrs by SRB assay
[PMID: 31718182]
B16-F10 IC50
64.7 μM
Compound: V; OA-Ac
Cytotoxicity against mouse B16F10 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against mouse B16F10 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 27128174]
B16-F10 IC50
64.7 μM
Compound: 5
Cytotoxicity against mouse B16F10 cells after 72 hrs by MTT assay
Cytotoxicity against mouse B16F10 cells after 72 hrs by MTT assay
[PMID: 24480359]
HepG2 IC50
> 100 μM
Compound: 10
Anticancer activity against human HepG2 cells assessed as cell viability after 48 hrs by MTT assay
Anticancer activity against human HepG2 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 24974349]
HepG2 IC50
103.67 μM
Compound: V; OA-Ac
Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 27128174]
HT-29 IC50
148.48 μM
Compound: V; OA-Ac
Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 27128174]
J774.A1 IC50
16.8 μM
Compound: 2
Inhibition of LPS-induced NO production in mouse J774A1 cells compound preincubated for 1 hr before LPS treatment by Griess reaction
Inhibition of LPS-induced NO production in mouse J774A1 cells compound preincubated for 1 hr before LPS treatment by Griess reaction
[PMID: 25113933]
J774.A1 IC50
80.34 μM
Compound: 2
Cytotoxicity against mouse J774A1 cells assessed as cell viability by MTT assay relative to control
Cytotoxicity against mouse J774A1 cells assessed as cell viability by MTT assay relative to control
[PMID: 25113933]
KB IC50
7.6 μM
Compound: 1
Antiproliferative activity against human KB cells incubated for 72 hrs by SRB assay
Antiproliferative activity against human KB cells incubated for 72 hrs by SRB assay
[PMID: 31718182]
MCF7 IC50
> 10 μM
Compound: 1
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by SRB assay
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by SRB assay
[PMID: 31718182]
MDA-MB-231 IC50
> 10 μM
Compound: 1
Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by SRB assay
Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by SRB assay
[PMID: 31718182]
Neutrophil IC50
> 10 μg/mL
Compound: Table 3, R21C1
Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation by measuring superoxide dismutase SOD-inhibitable ferricytochrome c reduction incubated for 5 mins before fMLP/CB stimulation for 3 mins
Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation by measuring superoxide dismutase SOD-inhibitable ferricytochrome c reduction incubated for 5 mins before fMLP/CB stimulation for 3 mins
[PMID: 28218000]
Neutrophil IC50
> 10 μg/mL
Compound: Table 3, R21C1
Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release pre-incubated for 5 mins before fMLP/CB stimulation using MeO-Suc-Ala-Ala-Pro-Val-pnitroanilide as substrate
Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release pre-incubated for 5 mins before fMLP/CB stimulation using MeO-Suc-Ala-Ala-Pro-Val-pnitroanilide as substrate
[PMID: 28218000]
RAW264.7 IC50
13.8 μM
Compound: 2
Inhibition of LPS-induced NO production in mouse RAW264.7 cells compound preincubated for 1 hr before LPS treatment by Griess reaction
Inhibition of LPS-induced NO production in mouse RAW264.7 cells compound preincubated for 1 hr before LPS treatment by Griess reaction
[PMID: 25113933]
RAW264.7 IC50
79.23 μM
Compound: 2
Cytotoxicity mouse RAW264.7 cells assessed as cell viability by MTT assay relative to control
Cytotoxicity mouse RAW264.7 cells assessed as cell viability by MTT assay relative to control
[PMID: 25113933]
分子量

498.74

Formula

C32H50O4
CAS 号
性状

固体

颜色

White to off-white

中文名称

齐墩果酸3-乙酸酯
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 2 mg/mL (4.01 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0051 mL 10.0253 mL 20.0505 mL
5 mM --- --- ---
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

3-​O-​Acetyloleanolic acid 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0051 mL 10.0253 mL 20.0505 mL 50.1263 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-​O-​Acetyloleanolic acid4339-72-4齐墩果酸3-乙酸酯ApoptosisInhibitorinhibitorinhibit

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