2. Cell Cycle/DNA Damage Epigenetics
  3. PARP
  4. 4'-Methoxychalcone

4'-Methoxychalcone  (Synonyms: 4'-甲氧基查尔酮)

目录号: HY-128400 纯度: 99.82%
COA 产品使用指南

摩尔计算器

4'-Methoxychalcone 通过 PPARγ 活化调节脂肪细胞分化，并调节参与胰岛素敏感性的脂肪组织中各种脂肪因子的表达和分泌。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

4'-Methoxychalcone Chemical Structure

4'-Methoxychalcone Chemical Structure

CAS No. : 959-23-9

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
25 mg ￥350
In-stock
50 mg ￥620
In-stock
100 mg ￥1200
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

4'-Methoxychalcone 相关抗体

Top Publications Citing Use of Products

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

4'-Methoxychalcone regulates adipocyte differentiation through PPARγ activation. 4'-Methoxychalcone modulates the expression and secretion of various adipokines in adipose tissue that are involved in insulin sensitivity[1].

IC50 & Target

PPARγ[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A2780 GI50
6.8 μM
Compound: 17
Antiproliferative activity against human A2780 cells assessed as cell growth inhibition measured after 72 hrs by trypan blue assay
Antiproliferative activity against human A2780 cells assessed as cell growth inhibition measured after 72 hrs by trypan blue assay
[PMID: 34262643]
CAL-51 GI50
3.33 μM
Compound: SSE14109
Antiproliferative activity against human CAL51 cells assessed as growth inhibition after 3 days by SRB assay
Antiproliferative activity against human CAL51 cells assessed as growth inhibition after 3 days by SRB assay
[PMID: 28743509]
DLD-1 EC50
35 μM
Compound: 7
Cytotoxicity against human DLD-1 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay
Cytotoxicity against human DLD-1 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay
[PMID: 36356534]
FHC CC50
62 μM
Compound: 7
Cytotoxicity against human FHC cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay
Cytotoxicity against human FHC cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay
[PMID: 36356534]
HCT-116 EC50
16 μM
Compound: 7
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay
[PMID: 36356534]
HCT-116 EC50
17 μM
Compound: 7
Cytotoxicity against p53-/- human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay
Cytotoxicity against p53-/- human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay
[PMID: 36356534]
HCT-116 GI50
3.57 μM
Compound: SSE14109
Antiproliferative activity against human HCT116 cells assessed as growth inhibition after 3 days by SRB assay
Antiproliferative activity against human HCT116 cells assessed as growth inhibition after 3 days by SRB assay
[PMID: 28743509]
HT-29 GI50
11.7 μM
Compound: 17
Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition measured after 72 hrs by trypan blue assay
Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition measured after 72 hrs by trypan blue assay
[PMID: 34262643]
HT-29 EC50
23 μM
Compound: 7
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay
[PMID: 36356534]
L929 CC50
50.4 μM
Compound: 13
Cytotoxicity in mouse NCTC-929 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity in mouse NCTC-929 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 31000155]
MSTO-211H GI50
11.7 μM
Compound: 17
Antiproliferative activity against human MSTO-211H cells assessed as cell growth inhibition measured after 72 hrs by trypan blue assay
Antiproliferative activity against human MSTO-211H cells assessed as cell growth inhibition measured after 72 hrs by trypan blue assay
[PMID: 34262643]
体外研究
(In Vitro)

4'-Methoxychalcone (5 μM; 8 days) markedly increases the mRNA expression of adipogenic genes during adipocyte differentiation, PPARγ, aP2, FAS, adiponectin and GluT 4[1].
4'-Methoxychalcone (5 μM; 8 days) reduces the upregulated mRNA expression of IL-6, PAI-1, and MCP-1 by TNF-α in preadipocyte 3T3-L1 cells[1].
4'-Methoxychalcone (5 μM; 0-8 days) causes an increase in PPARγ expression during differentiation, while C/EBPβ protein expression is relatively unaffected[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

4'-Methoxychalcone 相关抗体:

RT-PCR[1]

Cell Line: Preadipocyte 3T3-L1 cells
Concentration: 5 μM
Incubation Time: 0 day; 2 days; 4 days; 6 days; 8 days
Result: Increased the mRNA expression of all adipogenic genes, except GluT1 in adipocyte.

Western Blot Analysis[1]

Cell Line: Preadipocyte 3T3-L1 cells
Concentration: 5 μM
Incubation Time: 8 days
Result: Increased PPARγ expression in adipocyte.
分子量

238.28

Formula

C16H14O2
CAS 号
性状

固体

颜色

White to light yellow

中文名称

4'-甲氧基查尔酮
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 50 mg/mL (209.84 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.1967 mL 20.9837 mL 41.9674 mL
5 mM 0.8393 mL 4.1967 mL 8.3935 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

请根据您的 实验动物和给药方式 选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 方案 一

    请依序添加每种溶剂： 10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (10.49 mM); 澄清溶液

    此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
请输入您的动物体内配方组成：
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。
方案所需 助溶剂 包括：DMSO， ，均可在 MCE 网站选购。 ，Tween 80，均可在 MCE 网站选购。
计算结果
工作液所需浓度 : mg/mL
储备液配制方法 : mg 药物溶于 μL  DMSO（母液浓度为 mg/mL）。
您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。
动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。
连续给药周期超过半月以上，请谨慎选择该方案。
请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热 （超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。
纯度 & 产品资料

纯度: 99.82%

COA (283 KB) HNMR (228 KB) LCMS (89 KB)

产品使用指南 (1538 KB)
参考文献

4'-Methoxychalcone 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.1967 mL 20.9837 mL 41.9674 mL 104.9186 mL
5 mM 0.8393 mL 4.1967 mL 8.3935 mL 20.9837 mL
10 mM 0.4197 mL 2.0984 mL 4.1967 mL 10.4919 mL
15 mM 0.2798 mL 1.3989 mL 2.7978 mL 6.9946 mL
20 mM 0.2098 mL 1.0492 mL 2.0984 mL 5.2459 mL
25 mM 0.1679 mL 0.8393 mL 1.6787 mL 4.1967 mL
30 mM 0.1399 mL 0.6995 mL 1.3989 mL 3.4973 mL
40 mM 0.1049 mL 0.5246 mL 1.0492 mL 2.6230 mL
50 mM 0.0839 mL 0.4197 mL 0.8393 mL 2.0984 mL
60 mM 0.0699 mL 0.3497 mL 0.6995 mL 1.7486 mL
80 mM 0.0525 mL 0.2623 mL 0.5246 mL 1.3115 mL
100 mM 0.0420 mL 0.2098 mL 0.4197 mL 1.0492 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4'-Methoxychalcone959-23-94'-甲氧基查尔酮PARPpoly ADP ribose polymeraseInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
4'-Methoxychalcone
目录号：
HY-128400
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z