2. PI3K/Akt/mTOR TGF-beta/Smad Epigenetics Cell Cycle/DNA Damage Apoptosis
  3. Akt PKC CDK Apoptosis
  4. 7-Hydroxystaurosporine

7-Hydroxystaurosporine  (Synonyms: UCN-01; KRX-0601)

目录号: HY-13661
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摩尔计算器

7-Hydroxystaurosporine (UCN-01) 是一种 Staurosporine (HY-15141) 衍生物，具有抗肿瘤活性。7-Hydroxystaurosporine 抑制丝氨酸/苏氨酸激酶 AKT 和钙依赖性 protein kinase C 的活性。7-Hydroxystaurosporine 还间接激活细胞周期依赖性激酶 (CDKs)。7-Hydroxystaurosporine 使肿瘤细胞停滞在细胞周期的 G1/S 期，并通过抑制 G2 检查点激酶 chk1 来防止核苷酸切除修复，从而导致细胞凋亡 (apoptosis)。

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7-Hydroxystaurosporine Chemical Structure

7-Hydroxystaurosporine Chemical Structure

CAS No. : 112953-11-4

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7-Hydroxystaurosporine 相关抗体

Top Publications Citing Use of Products

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Akt Akt1 Akt2 Akt3

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKCι

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

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生物活性

7-Hydroxystaurosporine (UCN-01) is a synthetic derivative of Staurosporine (HY-15141) with antitumor activity. 7-hydroxystaurosporine inhibits serine/threonine kinase AKT and calcium-dependent protein kinase C activity. 7-hydroxystaurosporine also activates indirectly cyclin-dependent kinases (CDKs). 7-hydroxystaurosporine arrests tumor cells in the G1/S of the cell cycle and prevents nucleotide excision repair by inhibiting the G2 checkpoint kinase chk1, resulting in apoptosis[1][2].

分子量

482.53

Formula

C28H26N4O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

7-Hydroxystaurosporine 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

7-Hydroxystaurosporine112953-11-4UCN-01 KRX-0601UCN01UCN 01KRX0601KRX 0601KRX-0601AktPKCCDKApoptosisPKBProtein kinase BProtein kinase CCyclin dependent kinaseantitumor activityAKTprotein kinase CCDKstumor cellsnucleotide excision repairapoptosisInhibitorinhibitorinhibit

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