2. GPCR/G Protein
  3. LPL Receptor
  4. S1P1 agonist 1

S1P1 Agonist 1是具有免疫调节活性的 S1P1 激动剂。

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S1P1 agonist 1 Chemical Structure

S1P1 agonist 1 Chemical Structure

CAS No. : 1220973-37-4

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S1P1 agonist 1 相关抗体

Top Publications Citing Use of Products

查看 LPL Receptor 亚型特异性产品:

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LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

S1P1 Agonist 1 is a S1P1 agonist with immunomodulatory activities.

IC50 & Target

S1P1[1]
体外研究
(In Vitro)

S1P1 Agonist 1 binds to S1P1 is internalized and activates intracellular AKT and ERKs cellular signaling pathways. S1P1 Agonist 1 mediated S1P1 downregulation is independent of sphingosine kinase activity indicating it to be a direct agonist of S1P1. S1P1 Agonist 1 decreases cell surface expression of S1P1 in in vitro cell culture model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

S1P1 agonist 1 相关抗体:
体内研究
(In Vivo)

S1P1 Agonist 1 (1.3mg/kg) attenuates EAE disease. EAE is the animal model of multiple sclerosis which is extensively used for investigating clinical studies for multiple sclerosis drugs. S1P1 Agonist 1 treatment reduces peripheral total blood lymphocyte and T lymphocyte counts significantly. The reduction in total lymphocytes and T cells are 48% and 41% in AKP-11 treated animals, respectively. The reduction in the CD4+ and CD8+ T cell populations are 41% and 40% in S1P1 Agonist 1 treated animals, respectively. S1P1 Agonist 1 treatment reduces CNS infiltration of T cells and Cytokines and enhances neuroprotection. S1P1 Agonist 1 treatment has little effect on the heart rate of animals. The decrease in blood pressure is also smaller with S1P1 Agonist 1 treatment as compared animals treated with FTY720[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

443.88

Formula

C22H22ClN3O5
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 125 mg/mL (281.61 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.2529 mL 11.2643 mL 22.5286 mL
5 mM 0.4506 mL 2.2529 mL 4.5057 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献
Animal Administration
[1]

Rats: EAE is induced in female Lewis rats with guinea pig MBP (25 μg/rat). EAE developed rats are divided into 3 groups on day 11 or 12 after immunization and administered vehicle or S1P1 Agonist 1 (3 or 1.3 mg/kg) or FTY720 (1 mg/kg) orally every day until day 26. Rats are administrated orally with 1.3 mg/kg S1P1 Agonist 1, 1 mg/kg FTY720 and vehicle. After post administration, heart rates are measured at 1, 2, 4, 6, 12, and 24 hr[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

S1P1 agonist 1 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2529 mL 11.2643 mL 22.5286 mL 56.3215 mL
5 mM 0.4506 mL 2.2529 mL 4.5057 mL 11.2643 mL
10 mM 0.2253 mL 1.1264 mL 2.2529 mL 5.6322 mL
15 mM 0.1502 mL 0.7510 mL 1.5019 mL 3.7548 mL
20 mM 0.1126 mL 0.5632 mL 1.1264 mL 2.8161 mL
25 mM 0.0901 mL 0.4506 mL 0.9011 mL 2.2529 mL
30 mM 0.0751 mL 0.3755 mL 0.7510 mL 1.8774 mL
40 mM 0.0563 mL 0.2816 mL 0.5632 mL 1.4080 mL
50 mM 0.0451 mL 0.2253 mL 0.4506 mL 1.1264 mL
60 mM 0.0375 mL 0.1877 mL 0.3755 mL 0.9387 mL
80 mM 0.0282 mL 0.1408 mL 0.2816 mL 0.7040 mL
100 mM 0.0225 mL 0.1126 mL 0.2253 mL 0.5632 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S1P1 agonist 11220973-37-4LPL ReceptorLysophospholipid ReceptorInhibitorinhibitorinhibit

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