2. Vitamin D Related/Nuclear Receptor Apoptosis
  3. VD/VDR Apoptosis
  4. Eldecalcitol

Eldecalcitol  (Synonyms: 艾地骨化醇; ED-71; 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3)

目录号: HY-A0020 纯度: 99.86%
COA 产品使用指南

摩尔计算器

Eldecalcitol (ED-71) 是一种具有口服活性维生素 D3 类似物，可抑制骨吸收并增加骨密度。Eldecalcitol 具有抗肿瘤作用，抑制细胞增殖、迁移，并通过抑制 GPx-1 来诱导细胞凋亡 (apoptosis)。

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Eldecalcitol Chemical Structure

Eldecalcitol Chemical Structure

CAS No. : 104121-92-8

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1 mg ￥1600
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Customer Review

Other Forms of Eldecalcitol:

Eldecalcitol 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Eldecalcitol (ED-71) is an orally active vitamin D3 analogue, inhibits bone resorption and increases bone mineral density. Eldecalcitol (ED-71) displays anti-tumor effect and inhibits cell proliferation, migration and induces apoptosis by suppressing GPx-1[1][2][3][4].

体外研究
(In Vitro)

Eldecalcitol (0-50 nM；24 小时) 没有细胞毒性，可 (0.5-50 nM；24 小时) 减少 LPS (5 μg/mL) 诱导的细胞死亡[2]。
Eldecalcitol (5 nM；24 h) 通过激活 Nrf2 及其效应分子 HO-1[2]抑制 LPS 诱导的细胞焦亡。
Eldecalcitol (0.5-50 nM；24 h) 具有抗细胞焦亡能力，并以剂量依赖性方式降低 NLRP3、caspase-1 和 IL-1β 的表达[3]。
Eldecalcitol (0.04-40 nM；0-48 h) 抑制SCC-15 和 CAL-27 细胞的增殖和迁移[3]。
Eldecalcitol (0.4 nM；48 h) 使细胞周期停滞在 G0/G1 期，并通过抑制GPx-1 (谷胱甘肽过氧化物酶) 在胃癌细胞中的表达[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Eldecalcitol 相关抗体:

Western Blot Analysis[2]

Cell Line: Human gingival fibroblasts (HGFs)
Concentration: 0, 0.5, 5, and 50 nM
Incubation Time: 24 hours
Result: Decreased TLR4, NLRP3, caspase-1 p20, ASC, and GSDMD-N level in a dose-dependent manner compared with the group treated with LPS.
Reduced the release of IL-1β and IL-18 induced by LPS to normal levels.

Cell Proliferation Assay[3]

Cell Line: SCC-15 and CAL-27 cells
Concentration: 0, 0.04, 0.4, 4, and 40 nM
Incubation Time: 6, 8, 12, 24, 48 hours
Result: Inhibited the cell viability of the OSCC cells to reach 50% at 24 h with 0.4 nM.

Cell Proliferation Assay[3]

Cell Line: OSCC cells
Concentration: 0.4 nM
Incubation Time: 48 hours
Result: Increased the proportion of cells at the late phases of apoptosis from 7.1% to 16.1%.
Upregulated Bax and caspase-3, downregulated Bcl-2.
Significantly triggered apoptosis in SCC- 15 and CAL- 27 cells.
体内研究
(In Vivo)

Eldecalcitol (0.5 μg/kg；口服；每周两次，持续 4 周) 通过抑制 GPx-1 (谷胱甘肽过氧化物酶) 显示出抗癌作用[3]。
Eldecalcitol (10，30，或 90 ng/kg；口服；每周 5 次，持续 12 周)，作为一种更有效的维生素 D3 类似物，可刺激局灶性骨形成 (微型模型) 并比骨化三醇更强烈地抑制骨吸收[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Xenograft tumor model in mice (male athymic nude BALB/c mice)[3]
Dosage: 0.5 μg/kg
Administration: Oral gavage; twice a week for 4 weeks
Result: Reduced the growth rate of tumors, and downregulated the expression levels of PCNA and MMP- 2 and upregulated the expression of Bax in the tumors.
Resulted in decrease of proliferation, the inhibition of migration, and the promotion of apoptosis.
Animal Model: Ovariectomized (OVX) rat model[4]
Dosage: 10, 30, or 90 ng/kg
Administration: Oral gavage; 5-times per week for 12 weeks
Result: Increased the lumbar and femoral BMD in a dose dependent manner. Stimulated focal bone formation that started without prior bone resorption, a process known as bone minimodeling.
Clinical Trial
分子量

490.72

Formula

C30H50O5
CAS 号
性状

固体

颜色

White to off-white

中文名称

艾尔骨化醇；艾地骨化醇
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶解性数据
细胞实验： 

Methanol 中的溶解度 : 8.33 mg/mL (16.98 mM; 超声助溶)

DMSO 中的溶解度 : 3.33 mg/mL (6.79 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0378 mL 10.1891 mL 20.3782 mL
5 mM 0.4076 mL 2.0378 mL 4.0756 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.94%

COA (266 KB) HNMR (187 KB) RP-HPLC (199 KB)

产品使用指南 (1538 KB)
参考文献

Eldecalcitol 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO / Methanol 1 mM 2.0378 mL 10.1891 mL 20.3782 mL 50.9455 mL
5 mM 0.4076 mL 2.0378 mL 4.0756 mL 10.1891 mL
Methanol 10 mM 0.2038 mL 1.0189 mL 2.0378 mL 5.0946 mL
15 mM 0.1359 mL 0.6793 mL 1.3585 mL 3.3964 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eldecalcitol104121-92-8ED-71 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3艾尔骨化醇艾地骨化醇ED71ED 71VD/VDRApoptosisVitamin DVitamin D receptorboneresorptionmineraldensityperiodontitisNLRP3 inflammasomehuman gingival fibroblastsHGFsLPS-inducedpyroptosisNrf2/HO-1osteoporosisanti-tumorproliferationmigrationGPx-1arrest cell cycleInhibitorinhibitorinhibit

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