2. Apoptosis
  3. TNF Receptor
  4. Hispidol

Hispidol  (Synonyms: (Z)-Hispidol)

目录号: HY-102040 纯度: 98.70%
COA 产品使用指南 技术支持

Hispidol ((Z)-Hispidol) 具有研究炎症性肠病的潜力，能够抑制 TNF-α 诱导的单核细胞对结肠上皮细胞的粘附，IC50 值为 0.50 μM。

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Hispidol Chemical Structure

Hispidol Chemical Structure

CAS No. : 5786-54-9

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规格 价格 是否有货 数量
1 mg ￥1066
In-stock
5 mg ￥2475
In-stock
10 mg ￥3500
In-stock
25 mg ￥5863
In-stock
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100 mg 现货 询价
200 mg 现货 询价
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Customer Review

Hispidol 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Hispidol ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 μM.

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HT-29 IC50
0.5 μM
Compound: 55
Inhibition of TNF-alpha-induced adhesion of BCECF-labeled human U937 cells to human HT-29 cells preincubated for 1 hr followed by TNF-alpha challenge measured after 3 hrs by fluorescence microscopic method
Inhibition of TNF-alpha-induced adhesion of BCECF-labeled human U937 cells to human HT-29 cells preincubated for 1 hr followed by TNF-alpha challenge measured after 3 hrs by fluorescence microscopic method
[PMID: 28646757]
RAW264.7 IC50
1.06 μM
Compound: 2c
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced PGE2 production treated 1 hr before LPS challenge measured after 24 hrs by EIA
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced PGE2 production treated 1 hr before LPS challenge measured after 24 hrs by EIA
[PMID: 21723122]
RAW264.7 IC50
38.7 μM
Compound: 2c
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess reaction
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess reaction
[PMID: 21723122]
RAW264.7 IC50
99.79 μM
Compound: 2c
Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay
Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay
[PMID: 21723122]
体外研究
(In Vitro)

Hispidol 对 TNF-α 诱导的单核细胞与结肠上皮细胞的粘附具有强效抑制作用 (>70%)，这是导致炎症性肠病 (IBD) 的标志性事件之一。Hispidol 对 TNF-α 诱导的单核细胞-结肠上皮细胞粘附以及 LPS 诱导的 TNF-α 表达表现出强烈的抑制活性，是 IBD 药物开发的优秀候选药物。hispidol 对 TNF-α 表达的这种抑制对应于对 AP-1 转录活性的额外抑制活性，AP-1 是高水平 TNF-α 表达所需的另一种转录因子[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Hispidol 相关抗体:
体内研究
(In Vivo)

口服 hispidol 可显著抑制 TNBS 诱导的大鼠结肠炎，且呈剂量依赖性。口服 hispidol 以剂量依赖的方式抑制 TNBS 诱导的结肠炎。体重下降和结肠组织水肿性炎症有明显恢复。更高剂量 (30 mg/kg) 的 hispidol 显示出与 300 mg/kg 柳氮磺胺吡啶相似的恢复效果。在结肠组织中，TNBS 会导致 MPO 水平显著升高，MPO 是一种炎症的生化标志物，它被 hispidol 以剂量依赖的方式显著抑制[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

254.24

Formula

C15H10O4
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 100 mg/mL (393.33 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.9333 mL 19.6665 mL 39.3329 mL
5 mM 0.7867 mL 3.9333 mL 7.8666 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献
Animal Administration
[1]

Rats: To study the effect of the drugs, hispidol (10 or 30 mg/Kg/day in corn oil) is administered orally once in a day, until 5 days after TNBS administration. The doses of 10 or 30 mg/kg are selected based on previous studies. The concentration of the compound inhibiting 70% and 90% (µM) cell-to-cell adhesion is selected and regarded as the in vivo test dose (mg/kg). Sulfasalazine (300 mg/Kg/day) is administered in corn oil as a positive control. On the 6th day, the rats are sacrificed and the severity of colitis and macroscopic ulceration are evaluated by two independent investigators who are blinded to the experiments. The colon tissues (5-7 cm proximal to rectum) are cut and used to measure the amount of myeloperoxidase and for the histological examinations[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Hispidol 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9333 mL 19.6665 mL 39.3329 mL 98.3323 mL
5 mM 0.7867 mL 3.9333 mL 7.8666 mL 19.6665 mL
10 mM 0.3933 mL 1.9666 mL 3.9333 mL 9.8332 mL
15 mM 0.2622 mL 1.3111 mL 2.6222 mL 6.5555 mL
20 mM 0.1967 mL 0.9833 mL 1.9666 mL 4.9166 mL
25 mM 0.1573 mL 0.7867 mL 1.5733 mL 3.9333 mL
30 mM 0.1311 mL 0.6555 mL 1.3111 mL 3.2777 mL
40 mM 0.0983 mL 0.4917 mL 0.9833 mL 2.4583 mL
50 mM 0.0787 mL 0.3933 mL 0.7867 mL 1.9666 mL
60 mM 0.0656 mL 0.3278 mL 0.6555 mL 1.6389 mL
80 mM 0.0492 mL 0.2458 mL 0.4917 mL 1.2292 mL
100 mM 0.0393 mL 0.1967 mL 0.3933 mL 0.9833 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hispidol5786-54-9(Z)-HispidolTNF ReceptorTumor Necrosis Factor ReceptorTNFRInhibitorinhibitorinhibit

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