2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Hypotaurine

Hypotaurine  (Synonyms: 亚牛磺酸; 2-Aminoethanesulfinic acid)

目录号: HY-100803 纯度: 99.88%
COA 产品使用指南

摩尔计算器

Hypotaurine (2-aminoethanesulfinic acid) 是星形胶质细胞中半胱氨酸的牛磺酸生物合成中间体，是甘氨酸受体 (glycine receptor) 的内源性抑制性氨基酸。抗氧化剂。

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Hypotaurine Chemical Structure

Hypotaurine Chemical Structure

CAS No. : 300-84-5

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规格 价格 是否有货 数量
10 mM * 1 mL in Water ￥770
In-stock
50 mg ￥700
In-stock
100 mg   询价  
200 mg   询价  

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Customer Review

Hypotaurine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Hypotaurine (2-aminoethanesulfinic acid), an intermediate in taurine biosynthesis from cysteine in astrocytes, is an endogenous inhibitory amino acid of the glycine receptor. Antioxidant[1].

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Hypotaurine and taurine are found to reside within the cytosolic compartment of the cell. The ratio of taurine to hypotaurine is approx 50:1. The cytosolic concentration of taurine is approx. 50 mM. The concentration of hypotaurine decreases by 80% when resting neutrophils are converted into actively respiring cells by exposure to opsonized zymosan[1]. Hypotaurine activates hypoxia signaling through the competitive inhibition of prolyl hydroxylase domain-2. This leads to the activation of hypoxia signaling as well as to the enhancement of glioma cell proliferation and invasion[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Hypotaurine 相关抗体:
体内研究
(In Vivo)

Hypotaurine has antinociceptive effects on thermal, mechanical, and chemical nociception in the spinal cord. In CCI rats, hypotaurine alleviates mechanical allodynia and thermal hyperalgesia. Intrathecal hypotaurine suppresses acute, inflammatory, and neuropathic pain. Hypotaurine may regulate nociceptive transmission physiologically by activating glycinergic neurons in the spinal cord[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

109.15

Formula

C2H7NO2S
CAS 号
性状

固体

颜色

White to off-white

中文名称

亚牛磺酸；氨乙基亚磺酸
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

H2O 中的溶解度 : 125 mg/mL (1145.21 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 9.1617 mL 45.8085 mL 91.6170 mL
5 mM 1.8323 mL 9.1617 mL 18.3234 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂： PBS

    Solubility: 100 mg/mL (916.17 mM); 澄清溶液; 超声助溶

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.88%

COA (281 KB) HNMR (229 KB) LCMS (102 KB)

产品使用指南 (1538 KB)
参考文献
Animal Administration
[3]

Rats: A radiant heat source is focused on the middle part of the rat’s tail. The time interval from the onset of the stimulus until the tail flick response is measured using a tail flick unit. The intensity of the radiant heat is adjusted to give a tail flick latency of 4–5 s before the administration of hypotaurine or saline. In the absence of a response, the stimulus is terminated after 15 s (cutoff) to prevent tissue damage. The effects of hypotaurine (100, 200, 400, and 600 μg) on thermal nociception are assessed repeatedly for 120 min post-injection[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Hypotaurine 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 9.1617 mL 45.8085 mL 91.6170 mL 229.0426 mL
5 mM 1.8323 mL 9.1617 mL 18.3234 mL 45.8085 mL
10 mM 0.9162 mL 4.5809 mL 9.1617 mL 22.9043 mL
15 mM 0.6108 mL 3.0539 mL 6.1078 mL 15.2695 mL
20 mM 0.4581 mL 2.2904 mL 4.5809 mL 11.4521 mL
25 mM 0.3665 mL 1.8323 mL 3.6647 mL 9.1617 mL
30 mM 0.3054 mL 1.5270 mL 3.0539 mL 7.6348 mL
40 mM 0.2290 mL 1.1452 mL 2.2904 mL 5.7261 mL
50 mM 0.1832 mL 0.9162 mL 1.8323 mL 4.5809 mL
60 mM 0.1527 mL 0.7635 mL 1.5270 mL 3.8174 mL
80 mM 0.1145 mL 0.5726 mL 1.1452 mL 2.8630 mL
100 mM 0.0916 mL 0.4581 mL 0.9162 mL 2.2904 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hypotaurine300-84-52-Aminoethanesulfinic acid亚牛磺酸氨乙基亚磺酸Endogenous MetaboliteInhibitorinhibitorinhibit

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