2. Immunology/Inflammation
  3. NO Synthase
  4. Kuwanon A

Kuwanon A  (Synonyms: 桑皮酮A)

目录号: HY-N2300 纯度: 99.69%
COA 产品使用指南

摩尔计算器

Kuwanon A是从桑树 (Morus alba L.) 的根皮中分离的的黄酮衍生物，抑制一氧化氮产生的IC50值为10.5 μM。

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Kuwanon A Chemical Structure

Kuwanon A Chemical Structure

CAS No. : 62949-77-3

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Kuwanon A 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

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nNOS iNOS eNOS

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Kuwanon A is a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L.); inhibits nitric oxide production with an IC50 of 10.5 μM.

IC50 & Target

IC50: 10.5 μM (nitric oxide)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
5.3 μM
Compound: 4
Inhibition of human recombinant BACE-1 expressed in HEK293 cells assessed as inhibition of amyloid precursor protein cleavage into amyloid beta after 60 mins using Rh-EVNLDAEFK-Quencher as a substrate by FRET assay
Inhibition of human recombinant BACE-1 expressed in HEK293 cells assessed as inhibition of amyloid precursor protein cleavage into amyloid beta after 60 mins using Rh-EVNLDAEFK-Quencher as a substrate by FRET assay
[PMID: 21511472]
体外研究
(In Vitro)

Kuwanon A shows significant inhibitory activity towards the differentiation of 3T3-L1 adipocytes with TG inhibition values of 47.1%. Kuwanon A also shows significant nitric oxide (NO) production inhibitory effects in RAW264.7 cells with an IC50 of 10.5 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Kuwanon A 相关抗体:
分子量

420.45

Formula

C25H24O6
CAS 号
性状

固体

颜色

Light yellow to yellow

中文名称

桑皮酮A；桑酮A；桑黄酮A
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: 99.69%

COA (197 KB) HNMR (224 KB) CNMR (231 KB) RP-HPLC (270 KB) MS (221 KB)

产品使用指南 (1538 KB)
参考文献
Cell Assay
[1]

RAW264.7 cells are treated with Kuwanon A (3, 10, 20, 30, 100 μM). Cell viability is measured using the MTT assay[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Kuwanon A 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kuwanon A62949-77-3桑皮酮A桑酮A桑黄酮ANO SynthaseNitric oxide synthasesNOSInhibitorinhibitorinhibit

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