2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. LMP744 hydrochloride

LMP744 hydrochloride  (Synonyms: MJ-III65 hydrochloride; NSC706744 hydrochloride)

目录号: HY-U00248A 纯度: 99.70%
COA 产品使用指南

摩尔计算器

LMP744 hydrochloride (MJ-III65 hydrochloride) 是一种 DNA 嵌和剂，是 拓扑异构酶 1 (Top1) 抑制剂，具有抗肿瘤活性。

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LMP744 hydrochloride Chemical Structure

LMP744 hydrochloride Chemical Structure

CAS No. : 308246-57-3

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规格 价格 是否有货 数量
1 mg ￥1500
In-stock
5 mg ￥2900
In-stock
10 mg ￥4500
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

Other Forms of LMP744 hydrochloride:

LMP744 hydrochloride 相关抗体

Top Publications Citing Use of Products

查看 Topoisomerase 亚型特异性产品:

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Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity[1].

IC50 & Target

Top1

 

体外研究
(In Vitro)

The GI50 value of LMP744 (MJ-III-65) for NCI60 cells is 0.1 μM[2].
LMP744 (0.1-5 μM, 3 days) induces dose-dependent accumulation of cells in the S and G2 phases of the cell cycle[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LMP744 hydrochloride 相关抗体:

Cell Cytotoxicity Assay[2]

Cell Line: P388 and P388 Top1-deficient murine leukemia cells.
Concentration: 0.1-100 μM
Incubation Time: 3 days
Result: Induced dose-dependent accumulation of cells in the S and G2 phases of the cell cycle.
体内研究
(In Vivo)

LMP744 (MJ-III-65) (10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic nude mice (nu/nu, female, 20-25 g, 8-12 weeks old) transplanted with A253 and FaDu human head and neck xenografts[1].
Dosage: 10, 25, or 50 mg/kg/week, 4 weeks
Administration: I.V. push via tail vein
Result: Moderately actived against human A253 and FaDu tumor xenografts without significant toxicity.
Clinical Trial
分子量

488.92

Formula

C24H25ClN2O7
CAS 号
性状

固体

颜色

Light brown to brown

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 105 mg/mL (214.76 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0453 mL 10.2266 mL 20.4532 mL
5 mM 0.4091 mL 2.0453 mL 4.0906 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.70%

COA (265 KB) LCMS (268 KB)

产品使用指南 (1538 KB)
参考文献

LMP744 hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0453 mL 10.2266 mL 20.4532 mL 51.1331 mL
5 mM 0.4091 mL 2.0453 mL 4.0906 mL 10.2266 mL
10 mM 0.2045 mL 1.0227 mL 2.0453 mL 5.1133 mL
15 mM 0.1364 mL 0.6818 mL 1.3635 mL 3.4089 mL
20 mM 0.1023 mL 0.5113 mL 1.0227 mL 2.5567 mL
25 mM 0.0818 mL 0.4091 mL 0.8181 mL 2.0453 mL
30 mM 0.0682 mL 0.3409 mL 0.6818 mL 1.7044 mL
40 mM 0.0511 mL 0.2557 mL 0.5113 mL 1.2783 mL
50 mM 0.0409 mL 0.2045 mL 0.4091 mL 1.0227 mL
60 mM 0.0341 mL 0.1704 mL 0.3409 mL 0.8522 mL
80 mM 0.0256 mL 0.1278 mL 0.2557 mL 0.6392 mL
100 mM 0.0205 mL 0.1023 mL 0.2045 mL 0.5113 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LMP744308246-57-3MJ-III65NSC706744LMP 744LMP-744NSC 706744NSC-706744TopoisomeraseInhibitorinhibitorinhibit

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目录号：
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