2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. Naloxone hydrochloride

Naloxone hydrochloride  (Synonyms: 盐酸纳洛酮)

目录号: HY-17417 纯度: 99.96%
COA 产品使用指南

摩尔计算器

Naloxone hydrochloride 是 Opioid receptor 的拮抗剂。Naloxone hydrochloride 可减轻阿片类药物过量引起的呼吸抑制。Naloxone hydrochloride 可能会引起肺水肿和心律失常。

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Naloxone hydrochloride Chemical Structure

Naloxone hydrochloride Chemical Structure

CAS No. : 357-08-4

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Customer Review

Other Forms of Naloxone hydrochloride:

Naloxone hydrochloride 相关抗体

Top Publications Citing Use of Products
Proliferation Assay

    Naloxone hydrochloride purchased from MCE. Usage Cited in: Eur J Pain. 2017 May;21(5):804-814.  [Abstract]

    The SCS1 (early SCS)-mediated increase in the ipsilateral:contralateral PWT ratio (compared to pre-SCS) is significantly reduced by the opioid receptor antagonist, Naloxone, which is administered 10 min before SCS1.

    查看 Opioid Receptor 亚型特异性产品:

    查看所有亚型
    μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

    • 生物活性

    • 实验参考方法

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Naloxone hydrochloride is an antagonist of Opioid receptor. Naloxone hydrochloride alleviates opioid-overdose-induced respiratory depression. Naloxone hydrochloride may cause pulmonary edema and cardiac arrhythmias[1].

    体内研究
    (In Vivo)

    Naloxone (2.0 mg/kg with constant infusion of 1.7 mg/kg/h) causes a significant improvement in neurobehavioral outcome which persists up to 4 weeks postinjury in rat. Naloxone treatment causes a modest and nonsignificant increase in mean arterial blood pressure (MAP)[1]. Naloxone (0.4 mg/kg) causes memory facilitation and antagonizes the amnestic effect of ACTH and epinephrine in rat[2]. Naloxone treatment diminishes the strength of the initial tetanus in a dose-related manner in cats. Naloxone (5 or 10 mg/kg, i.v.) causes subsequent doses of morphine to produce less PTP depression but has no effect on maximal twitch depression[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    363.84

    Formula

    C19H22ClNO4
    CAS 号
    性状

    固体

    颜色

    White to off-white

    中文名称

    盐酸纳洛酮
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    溶解性数据
    细胞实验： 

    H2O 中的溶解度 : 62.5 mg/mL (171.78 mM; 超声助溶)

    DMSO 中的溶解度 : ≥ 30 mg/mL (82.45 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    * "≥" means soluble, but saturation unknown.

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 2.7485 mL 13.7423 mL 27.4846 mL
    5 mM 0.5497 mL 2.7485 mL 5.4969 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物实验：

    以下溶解方案源自文献，仅供参考，建议您先取少量样品进行尝试。

    • 方案 一

      Naloxone is made up in a vehicle of 2% dimethylformamide (aqueous)[4].

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
    您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
    纯度 & 产品资料

    纯度: 99.96%

    COA (299 KB) HNMR (262 KB) RP-HPLC (283 KB) MS (69 KB)

    产品使用指南 (1538 KB)
    参考文献
    Animal Administration
    [2]

    Young adult Wistar rats are used in the assay: females for experiments l and 3 (age 50-70 days, weight 100-185 g) and males for experiments 2 and 4 (age 51-69 days, weight 140-200 g). The same apparatus is used for both: a 50×25×25 cm box made of plywood with a frontal glass wall, whose floor consists of 1 mm-caliber bronze bars spaced l0 mm apart. In task l, a 5 cm high, 25×25 cm wooden platform is introduced into the box so as to cover the left half of the grid. Rats are held gently by their bodies and loared onto the platform facing the rear left corner, at which time a quartz chronometer is activated. Time is counted until the animals stepped down from the platform and placed their four paws on the grid, upon which a 0.5 mA, 60 Hz footshock is continuously delivered until the animals return to the platform. In task 2 the platform is only 7 cm wide and covered only the leftmost seven bars of the grid; the footshock is of only 0.3 mA and is delivered in 0.4 msec pulses once every 2 sec until the animals climb back onto the platform. Immediately after training in each task the animals are withdrawn from the box injected i.p. with one of the following: saline (1.0 mL/kg), ACTH1-24 (0.2 or 2.0 μg/kg), epinephrine HCl (5.0 or 50.0 μg/kg), human β-endorphin (0.1 or 1.0 μg/kg), naloxone HCl (0.4 mg/kg), or ACTH or epinephrine given together with either β-endorphin or naloxone. All drugs are dissolved in saline to an injection volume of 1.0 mL/kg. Twenty-four hr after training the animals again are placed on the platform (the wide one for task 1, experiments 1 and 2, and the narrow one for task 2, experiments 3 and 4), and their latency to stepdown onto the grid again is measured as in the training session. A ceiling of 180 sec is imposed on this measure.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    参考文献

    Naloxone hydrochloride 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 2.7485 mL 13.7423 mL 27.4846 mL 68.7115 mL
    5 mM 0.5497 mL 2.7485 mL 5.4969 mL 13.7423 mL
    10 mM 0.2748 mL 1.3742 mL 2.7485 mL 6.8712 mL
    15 mM 0.1832 mL 0.9162 mL 1.8323 mL 4.5808 mL
    20 mM 0.1374 mL 0.6871 mL 1.3742 mL 3.4356 mL
    25 mM 0.1099 mL 0.5497 mL 1.0994 mL 2.7485 mL
    30 mM 0.0916 mL 0.4581 mL 0.9162 mL 2.2904 mL
    40 mM 0.0687 mL 0.3436 mL 0.6871 mL 1.7178 mL
    50 mM 0.0550 mL 0.2748 mL 0.5497 mL 1.3742 mL
    60 mM 0.0458 mL 0.2290 mL 0.4581 mL 1.1452 mL
    80 mM 0.0344 mL 0.1718 mL 0.3436 mL 0.8589 mL
    H2O 100 mM 0.0275 mL 0.1374 mL 0.2748 mL 0.6871 mL

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Naloxone357-08-4盐酸纳洛酮Opioid ReceptorInhibitorinhibitorinhibit

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