2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. Nicainoprol

Nicainoprol  (Synonyms: 尼卡普醇; RU-42924)

目录号: HY-100572 纯度: 99.86%
COA 产品使用指南

摩尔计算器

Nicainoprol 是一种快速钠通道 (sodium-channel) 阻断剂，是一种有效的抗心律失常剂。

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Nicainoprol Chemical Structure

Nicainoprol Chemical Structure

CAS No. : 76252-06-7

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规格 价格 是否有货 数量
1 mg ￥1330
In-stock
5 mg ￥3370
In-stock
10 mg   询价  
50 mg   询价  

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Customer Review

Nicainoprol 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nicainoprol is a fast-sodium-channel blocking agent, which is a potent antiarrhythmic agent.

IC50 & Target

Sodium Channel[1]
体外研究
(In Vitro)

The antiarrhythmic agent Nicainoprol, a fast-sodium-channel blocking drug, also protected isolated rat hearts against reperfusion arrhythmias, but is without beneficial effects on cardiac hemodynamics and biochemical parameters, in contrast to the ACE inhibitor[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nicainoprol 相关抗体:
体内研究
(In Vivo)

The effect of the novel antiarrhythmic agent Nicainoprol on coronary occlusion and reperfusion arrhythmia is investigated in isolated working rat hearts and in anesthetized rats. In isolated working rat hearts Nicainoprol (10 μM, 5 μM and 100 μM) induces concentration-related protection against reperfusion arrhythmia without changing the cardiodynamics, with the exception of a decrease in heart rate at the highest concentration. Enzyme levels (lactate dehydrogenase and creatine kinase) in the coronary venous effluent, and cardiac tissue concentrations of glycogen, lactate, ATP and creatine phosphate are not affected by Nicainoprol. Given to anesthetized rats, Nicainoprol (5 and 10 mg/kg i.v.) reduces dose dependently in the early post occlusion (0-30 min) period, the percentage of animals with premature ventricular complexes (PVCs) and ventricular tachycardia while completely preventing the occurrence of ventricular fibrillation. In the reperfusion period no animal treated with 5 mg/kg and 12% of the rats treated with 10 mg/kg showed PVCs (the only form of arrhythmia observed in this period) versus 60% of the control rats. Both doses of Nicainoprol induces a decrease in heart rate, blood pressure and myocardial oxygen consumption. The ratio of infarct mass to ventricular mass is significantly reduced by 20% at a dose of 5 mg/kg and by 28% at the dose of 10 mg/kg. Nicainoprol could be useful in the prevention and treatment of arrhythmias associated with acute myocardial infarction[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

369.46

Formula

C21H27N3O3
CAS 号
性状

固体

颜色

White to off-white

中文名称

尼卡普醇
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 125 mg/mL (338.33 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7067 mL 13.5333 mL 27.0665 mL
5 mM 0.5413 mL 2.7067 mL 5.4133 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.86%

COA (289 KB) HNMR (254 KB) LCMS (93 KB)

产品使用指南 (1538 KB)
参考文献

Nicainoprol 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7067 mL 13.5333 mL 27.0665 mL 67.6663 mL
5 mM 0.5413 mL 2.7067 mL 5.4133 mL 13.5333 mL
10 mM 0.2707 mL 1.3533 mL 2.7067 mL 6.7666 mL
15 mM 0.1804 mL 0.9022 mL 1.8044 mL 4.5111 mL
20 mM 0.1353 mL 0.6767 mL 1.3533 mL 3.3833 mL
25 mM 0.1083 mL 0.5413 mL 1.0827 mL 2.7067 mL
30 mM 0.0902 mL 0.4511 mL 0.9022 mL 2.2555 mL
40 mM 0.0677 mL 0.3383 mL 0.6767 mL 1.6917 mL
50 mM 0.0541 mL 0.2707 mL 0.5413 mL 1.3533 mL
60 mM 0.0451 mL 0.2256 mL 0.4511 mL 1.1278 mL
80 mM 0.0338 mL 0.1692 mL 0.3383 mL 0.8458 mL
100 mM 0.0271 mL 0.1353 mL 0.2707 mL 0.6767 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nicainoprol76252-06-7RU-42924尼卡普醇RU42924RU 42924Sodium ChannelNa channelsNa+ channelsInhibitorinhibitorinhibit

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