2. Anti-infection
  3. HSV
  4. Penciclovir

Penciclovir  (Synonyms: 喷昔洛韦; BRL 39123; VSA 671)

目录号: HY-17424 纯度: 99.92%
COA 产品使用指南

摩尔计算器

Penciclovir (VSA 671) 是一种有效的选择性抗疱疹病毒 (anti-herpesvirus) 剂，对于 HSV-1（HFEM），HSV-2（MS） 的 EC50 值分别为 0.5, 0.8 µg/ml。Penciclovir 显示抗疱疹病毒活性且无细胞毒性。Penciclovir 可防止小鼠死亡。

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Penciclovir Chemical Structure

Penciclovir Chemical Structure

CAS No. : 39809-25-1

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥280
In-stock
50 mg ￥250
In-stock
100 mg ￥400
In-stock
200 mg   询价  
500 mg   询价  

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Other Forms of Penciclovir:

Penciclovir 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

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HSV-1 HSV-2 HSV

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Penciclovir (VSA 671) is a potent and selective anti-herpesvirus agent with EC50 values of 0.5, 0.8 µg/ml for HSV-1 (HFEM), HSV-2 (MS), respectively. Penciclovir shows anti-herpesvirus activity with no-toxic. Penciclovir preventes mortality in mouse[1][2].

IC50 & Target[1]

HSV-1

0.5 μg/mL (EC50)

HSV-2

0.8 μg/mL (EC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEL CC50
> 100 μM
Compound: 2
Cytotoxicity against human HEL cells assessed as cell growth inhibition by cell counting method
Cytotoxicity against human HEL cells assessed as cell growth inhibition by cell counting method
[PMID: 28829913]
HEL CC50
> 395 μM
Compound: Penciclovir
Cytotoxicity against HEL cells assessed as reduction in cell viability after 3 days by coulter counting method
Cytotoxicity against HEL cells assessed as reduction in cell viability after 3 days by coulter counting method
[PMID: 29670705]
HepG2 EC50
0.19 μM
Compound: Penciclovir (PCV)
Effective concentration necessary to decrease extracellular Hepatitis B virus DNA levels by 50% in human hepatoblastoma cell line (2.2.15 cells) in vitro
Effective concentration necessary to decrease extracellular Hepatitis B virus DNA levels by 50% in human hepatoblastoma cell line (2.2.15 cells) in vitro
10.1016/S0960-894X(97)00422-8
HepG2 IC50
433 μM
Compound: Penciclovir (PCV)
Cytotoxicity towards human hepatoblastoma cell line (2.2.15 cells) measured by inhibition of neutral red dye uptake in vitro
Cytotoxicity towards human hepatoblastoma cell line (2.2.15 cells) measured by inhibition of neutral red dye uptake in vitro
10.1016/S0960-894X(97)00422-8
HepG2 2.2.15 EC50
3.4 μM
Compound: Penciclovir
Antiviral activity against Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as reduction in viral DNA by Southern blotting
Antiviral activity against Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as reduction in viral DNA by Southern blotting
[PMID: 21333535]
HepG2 2.2.15 CC50
552 μM
Compound: Penciclovir
Cytotoxicity against human HepG2(2.2.15) cells by neutral red dye uptake assay
Cytotoxicity against human HepG2(2.2.15) cells by neutral red dye uptake assay
[PMID: 21333535]
MRC5 IC50
16 μM
Compound: Penciclovir
Antiviral activity against Varicella zoster virus Ellen infected in human MRC5 cells assessed as inhibition of viral replication by viral reduction plaque assay
Antiviral activity against Varicella zoster virus Ellen infected in human MRC5 cells assessed as inhibition of viral replication by viral reduction plaque assay
[PMID: 23219702]
MT4 IC50
> 150 μM
Compound: 2
Cytotoxicity against human MT4 cells assessed as reduction in cell viability by cell counting method
Cytotoxicity against human MT4 cells assessed as reduction in cell viability by cell counting method
[PMID: 28829913]
Vero CC50
> 500 μM
Compound: penciclovir
Compound was tested for cytotoxicity in Vero cells (concentration required to reduce the OD value by 50% of the control)
Compound was tested for cytotoxicity in Vero cells (concentration required to reduce the OD value by 50% of the control)
[PMID: 9719596]
Vero CC50
> 790 μM
Compound: PCV
Cytotoxicity against african green monkey Vero cells after 2 days
Cytotoxicity against african green monkey Vero cells after 2 days
[PMID: 17438061]
Vero EC50
17 μM
Compound: PCV
Antiviral activity against Herpes B virus 24105 infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs
Antiviral activity against Herpes B virus 24105 infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs
[PMID: 17438061]
Vero EC50
17.3 μM
Compound: PCV
Antiviral activity against Herpes B virus E90-136 infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs
Antiviral activity against Herpes B virus E90-136 infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs
[PMID: 17438061]
Vero EC50
25.3 μM
Compound: PCV
Antiviral activity against Herpes B virus 32425 infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs
Antiviral activity against Herpes B virus 32425 infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs
[PMID: 17438061]
Vero EC50
4.7 μM
Compound: PCV
Antiviral activity against Herpes simplex virus 1 F infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs
Antiviral activity against Herpes simplex virus 1 F infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs
[PMID: 17438061]
Vero C1008 CC50
> 400 μM
Compound: Penciclovir
Cytotoxicity against African green monkey Vero E6 cells assessed as reduction of cell viability measured after 48 hrs by CCK-8 assay
Cytotoxicity against African green monkey Vero E6 cells assessed as reduction of cell viability measured after 48 hrs by CCK-8 assay
[PMID: 32563814]
Vero C1008 CC50
> 400 μM
Compound: 54
Cytotoxicity against African green monkey Vero E6 cells by CCK-8 assay
Cytotoxicity against African green monkey Vero E6 cells by CCK-8 assay
[PMID: 33486200]
Vero C1008 CC50
> 400 μM
Compound: 50
Cytotoxicity against African green monkey Vero E6 cells by the CCK8 assay
Cytotoxicity against African green monkey Vero E6 cells by the CCK8 assay
[PMID: 32845145]
Vero C1008 CC50
> 400 μM
Compound: Penciclovir
Cytotoxicity against African green monkey Vero E6 cells by CCK8 assay
Cytotoxicity against African green monkey Vero E6 cells by CCK8 assay
[PMID: 32511912]
体外研究
(In Vitro)

Penciclovir (0-100 µg/ml) shows anti-herpesvirus activity with EC50s of 0.5, 0.8, 2.4, 52, 100, 1.2, 1.6, 0.9, >100 µg/ml for HSV-1 (HFEM), HSV-2 (MS), VZV (Ellen), CMV (AD-169), BHV-1 (Oxford 1964), BHV-2 (New York 1), EHV-1(Quai Hals), FHV-1 (B927), SVV, respectively[1].
Penciclovir (0-100 µg/ml) shows no-toxic to uninfected human cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Penciclovir 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: MRC-5,WISH, Flow 4000, Flow 12000, RPMI 2650, WI-38, WI-38 VA13, Hs68, HEp-2, RD, SCC-13,Primary cells
Concentration: 0-100 µg/ml
Incubation Time:
Result: Showed no-toxic with IC50s of >100, >100, 100, >100, 60, >100, >100, >100, >100, >100, >100, >100 for MRC-5,WISH, Flow 4000, Flow 12000, RPMI 2650, WI-38, WI-38 VA13, Hs68, HEp-2, RD, SCC-13,Primary cells, respectively.
体内研究
(In Vivo)

Penciclovir (100 mg/kg; s.c.; daily for 5 days) preventes mortality in mouse[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Three-week-old female Balb/c mice[2]
Dosage: 100 mg/kg
Administration: S.c.; daily for 5 days
Result: Reduced virus titres in the respiratory organs of both w/t- and PR3-infected mice.
Clinical Trial
分子量

253.26

Formula

C10H15N5O3
CAS 号
性状

固体

颜色

White to off-white

中文名称

喷昔洛韦
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 25 mg/mL (98.71 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H2O 中的溶解度 : 2 mg/mL (7.90 mM; 超声助溶 (<60°C))

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.9485 mL 19.7426 mL 39.4851 mL
5 mM 0.7897 mL 3.9485 mL 7.8970 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

请根据您的 实验动物和给药方式 选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 方案 一

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (9.87 mM); 澄清溶液

    此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水 定容至 1 mL。

    生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
  • 方案 二

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (9.87 mM); 澄清溶液

    此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液 中，混合均匀。

    2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。
动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
请输入您的动物体内配方组成：
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。
方案所需 助溶剂 包括：DMSO， ，均可在 MCE 网站选购。 ，Tween 80，均可在 MCE 网站选购。
计算结果
工作液所需浓度 : mg/mL
储备液配制方法 : mg 药物溶于 μL  DMSO（母液浓度为 mg/mL）。
您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。
动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。
连续给药周期超过半月以上，请谨慎选择该方案。
请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热 （超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。
纯度 & 产品资料
参考文献

Penciclovir 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 3.9485 mL 19.7426 mL 39.4851 mL 98.7128 mL
5 mM 0.7897 mL 3.9485 mL 7.8970 mL 19.7426 mL
DMSO 10 mM 0.3949 mL 1.9743 mL 3.9485 mL 9.8713 mL
15 mM 0.2632 mL 1.3162 mL 2.6323 mL 6.5809 mL
20 mM 0.1974 mL 0.9871 mL 1.9743 mL 4.9356 mL
25 mM 0.1579 mL 0.7897 mL 1.5794 mL 3.9485 mL
30 mM 0.1316 mL 0.6581 mL 1.3162 mL 3.2904 mL
40 mM 0.0987 mL 0.4936 mL 0.9871 mL 2.4678 mL
50 mM 0.0790 mL 0.3949 mL 0.7897 mL 1.9743 mL
60 mM 0.0658 mL 0.3290 mL 0.6581 mL 1.6452 mL
80 mM 0.0494 mL 0.2468 mL 0.4936 mL 1.2339 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Penciclovir39809-25-1BRL 39123 VSA 671喷昔洛韦BRL39123BRL-39123VSA671VSA 671VSA-671HSVHerpes simplex virusanti-herpesvirusno-toxicmortalityInhibitorinhibitorinhibit

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