2. Antibody-drug Conjugate/ADC Related Immunology/Inflammation
  3. Radionuclide-Drug Conjugates (RDCs) CD20
  4. Rituximab

Rituximab  (Synonyms: 利妥昔单抗; Anti-Human CD20 type I, Chimeric Antibody)

目录号: HY-P9913 纯度: 98.53%
COA

摩尔计算器

Rituximab 是一种抗 CD20 嵌合单克隆抗体，用于某些自身免疫疾病和癌症的研究。

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CAS No. : 174722-31-7

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规格 价格 是否有货 数量
1 mg ￥1900
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5 mg ￥5600
In-stock
10 mg ￥8680
In-stock
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100 mg   询价  

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Customer Review

Other Forms of Rituximab:

Rituximab 相关抗体

Top Publications Citing Use of Products

查看 Radionuclide-Drug Conjugates (RDCs) 亚型特异性产品:

查看所有亚型
RDC Peptide RDC Antibody RDC Bifunctional Chelator RDC Linker Other

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Rituximab is an anti-CD20 chimeric monoclonal antibody used for research of certain autoimmune diseases and cancer.

同型

Human IgG1 kappa
推荐同型对照抗体
种属

Chimeric
IC50 & Target

RDC Antibody

 

体外研究
(In Vitro)

Rituximab 抑制受刺激的人类 B 细胞的增殖，这与激活原初型 B 细胞比例相对增加有关。除了这种群体转移之外，各种 B 细胞亚群的表型或细胞因子谱没有发生重大变化。与未接受 Rituximab 刺激的 B 细胞相比，在利，在 Rituximab 存在下刺激的 B 细胞会诱导更强的 T 细胞增殖[1]。
所有测试的淋巴瘤细胞对抗体依赖性细胞介导的细胞毒性 (ADCC)、抗体介导的肿瘤细胞吞噬作用和 Rituximab 诱导的细胞凋亡同样敏感。Rituximab 抗诱导高度补体依赖的细胞毒性 (CDC) 以杀灭滤泡性淋巴瘤细胞[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Rituximab 相关抗体:
体内研究
(In Vivo)

在肿瘤接种后 1 天通过腹腔注射单次剂量的 Rituximab 或鼠源性抗 CD20 抗体 1F5，可治愈 100% 的动物。在肿瘤接种的动物中耗竭自然杀伤 (NK) 细胞或中性粒细胞，或同时耗竭这两种细胞，均不影响药物的治疗活性。同样，Rituximab 够在无胸腺裸鼠中根除肿瘤细胞，这表明其活性不依赖于 T 细胞[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

利妥昔单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Rituximab has a significant ADCC effect on Raji cells in a dose-dependent manner.The EC50 for this effect is 6.56 and 3.25 ng/mL.
纯度 & 产品资料

纯度: 99.85%

COA (172 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献
Cell Assay

A single injection of rituximab or the murine anti-CD20 Ab 1F5, given i.p. 1 day after the tumor, cures 100% of the animals. Depletion of either NK cells or neutrophils or both in tumor-injected animals does not affect the therapeutic activity of the drug. Similarly, rituximab is able to eradicate tumor cells in athymic nude mice, suggesting that its activity is T cell independent[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[1]

C57BL/6 mice (8-10 wk of age) are inoculated 8×103 EL4-CD20+ cells in 200 μL of saline by tail vein injection. In parallel groups of mice, 150 g of rituximab, murine anti-CD20 IgG2a Ab 1F5, or control anti-human IL-2R Ab daclizumab in 300 μL of saline, or saline only is inoculated i.p. 24 h later[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Rituximab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rituximab174722-31-7Anti-Human CD20 type I, Chimeric Antibody利妥昔单抗Radionuclide-Drug Conjugates (RDCs)CD20Inhibitorinhibitorinhibit

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