Phosphorylase (磷酸化酶)

Phosphorylase is an enzyme that catalyzes the addition of a phosphate group from an inorganic phosphate (phosphate+hydrogen) to an acceptor, including glycogen phosphorylase, starch phosphorylase, nucleoside diphosphate kinase, etc. Phosphorylase participates in cell signal transduction and activates signal pathways through phosphorylation. Phosphorylase plays a crucial role in metabolic processes and is extensively involved in the metabolic regulation of substances such as sugars, nucleotides, and lipids. Phosphorylase can also regulate cell differentiation, proliferation, apoptosis, and gene expression, affecting the fate and function of cells. Abnormal activity or expression of phosphorylase leads to metabolic diseases such as glycogen storage disease, and is also closely related to the occurrence and development of cancer, neurodegenerative diseases, etc^[1].