2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. Tetrahydroberberine

Tetrahydroberberine  (Synonyms: 四氢小檗碱; Canadine)

目录号: HY-N0925 纯度: 98.61%
COA 产品使用指南

摩尔计算器

四氢小檗碱 (Tetrahydroberberine) 是一种可从延胡索中分离得到的异喹啉类生物碱。Tetrahydroberberine 是一种口服有效的 D2 受体拮抗剂和 5-HT1A 受体激动剂，对 D2 和 5-HT1A 受体具有微摩尔级亲和力。Tetrahydroberberine 还能够增强胃肠道收缩，发挥神经保护作用。

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Tetrahydroberberine Chemical Structure

Tetrahydroberberine Chemical Structure

CAS No. : 522-97-4

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规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥242
In-stock
5 mg ￥220
In-stock
10 mg ￥350
In-stock
25 mg ￥583
In-stock
50 mg ￥849
In-stock
100 mg ￥1225
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Tetrahydroberberine:

Tetrahydroberberine 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

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Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

四氢小檗碱 (Tetrahydroberberine) This is a different kind of living thing that can be extended and divided into parts. Tetrahydroberberine is a kind of effective D2 receptor antagonistic force. Tetrahydroberberine has the ability to strengthen the stomach and relieve the pressure on the stomach.

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 30 μM
Compound: 9
Cytotoxicity against human A549 cells by SRB assay
Cytotoxicity against human A549 cells by SRB assay
[PMID: 20594848]
HCT-15 IC50
> 30 μM
Compound: 9
Cytotoxicity against human HCT15 cells by SRB assay
Cytotoxicity against human HCT15 cells by SRB assay
[PMID: 20594848]
PC-12 CC50
> 150 μM
Compound: 15
Cytotoxicity against rat PC12 cells assessed as reduction in cell viability incubated for 24 hrs by WST-8 assay
Cytotoxicity against rat PC12 cells assessed as reduction in cell viability incubated for 24 hrs by WST-8 assay
[PMID: 33611188]
SK-MEL-2 IC50
27.94 μM
Compound: 9
Cytotoxicity against human SK-MEL-2 cells by SRB assay
Cytotoxicity against human SK-MEL-2 cells by SRB assay
[PMID: 20594848]
SK-OV-3 IC50
> 30 μM
Compound: 9
Cytotoxicity against human SKOV3 cells by SRB assay
Cytotoxicity against human SKOV3 cells by SRB assay
[PMID: 20594848]
THP-1 IC50
8.35 nM
Compound: 3
Inhibition of tissue factor procoagulant activity in LPS-stimulated human THP1 cells preincubated for 1 hr before LPS addition measured after 5 hrs
Inhibition of tissue factor procoagulant activity in LPS-stimulated human THP1 cells preincubated for 1 hr before LPS addition measured after 5 hrs
[PMID: 23199480]
体外研究
(In Vitro)

Tetrahydroberberine (100 μM) 可阻断大鼠黑质紧密部 (SNc) 急剧分离的多巴胺能 (DA) 神经元中的 K(ATP) 通道，恢复 1 μM 鱼藤酮 (HY-B1756) 诱导的膜超极化[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tetrahydroberberine 相关抗体:
体内研究
(In Vivo)

Tetrahydroberberine (30 μg/kg; IV) 导致比格犬的胃调节能力急剧增加，在大鼠中显著增强胃收缩力和缩短收缩间隔，增强上胃肠道的胃运动功能[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

339.39

Formula

C20H21NO4
CAS 号
性状

固体

颜色

Light yellow to yellow

中文名称

四氢小檗碱
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 25 mg/mL (73.66 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9465 mL 14.7323 mL 29.4646 mL
5 mM 0.5893 mL 2.9465 mL 5.8929 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Tetrahydroberberine 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9465 mL 14.7323 mL 29.4646 mL 73.6616 mL
5 mM 0.5893 mL 2.9465 mL 5.8929 mL 14.7323 mL
10 mM 0.2946 mL 1.4732 mL 2.9465 mL 7.3662 mL
15 mM 0.1964 mL 0.9822 mL 1.9643 mL 4.9108 mL
20 mM 0.1473 mL 0.7366 mL 1.4732 mL 3.6831 mL
25 mM 0.1179 mL 0.5893 mL 1.1786 mL 2.9465 mL
30 mM 0.0982 mL 0.4911 mL 0.9822 mL 2.4554 mL
40 mM 0.0737 mL 0.3683 mL 0.7366 mL 1.8415 mL
50 mM 0.0589 mL 0.2946 mL 0.5893 mL 1.4732 mL
60 mM 0.0491 mL 0.2455 mL 0.4911 mL 1.2277 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tetrahydroberberine522-97-4Canadine四氢小檗碱Dopamine ReceptorInhibitorinhibitorinhibit

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