Tyloxapol  (Synonyms: 四丁酚醛; Triton WR1339)

Tyloxapol (Triton WR1339) is a nonionic liquid polymer of the alkyl aryl polyether alcohol type, used as a surface active stabilizer. Tyloxapol (Triton WR1339) is used to induce hyperlipidemia in animals^[1][2].

Tyloxapol (100 μg/mL) 触发 HEK293 细胞脱离^[2]。
Tyloxapol 诱导细胞核碎裂和凋亡细胞核的出现^[2]。< br/> Tyloxapol 会增加肺出血的风险，引起上皮细胞和红细胞的细胞毒性，并诱导人 Jurkat T 淋巴细胞裂解^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tyloxapol 可用于动物建模，构建大鼠高脂血症模型。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

261.38 (monomer)

(C₁₅H₂₁O(C₂H₄O)m)n

25301-02-4

液体（密度：1.1 g/cm³）

Colorless to light yellow

四丁酚醛；泰洛沙泊

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. de Sousa JA, et al. Evaluation of DNA damage in Wistar rat tissues with hyperlipidemia induced by tyloxapol. Exp Mol Pathol. 2017 Aug;103(1):51-55.  [Content Brief]

  [2]. Kuroda M, et al. Mechanism for elevation of hepatic cholesterol synthesis and serum cholesterol levels in triton WR-1339-induced hyperlipidemia. Biochim Biophys Acta. 1977 Oct 24;489(1):119-25.  [Content Brief]

  [3]. Heba Mohamed Abdou, et al. Triton WR-1339-induced hyperlipidemia, DNA fragmentation, neurotransmitters inhibition, oxidative damage, histopathological and morphometric changes: the protective role of soybean oil. The Journal of Basic and Applied Zoology volume 79, Article number: 51 (2018).

  [4]. Julijana Kristl, et al. Surface active stabilizer tyloxapol in colloidal dispersions exerts cytostatic effects and apoptotic dismissal of cells. Toxicol Appl Pharmacol. 2008 Oct 15;232(2):218-25.  [Content Brief]