2. Anti-infection
  3. Parasite
  4. Acetylastragaloside I

Acetylastragaloside I 是一种糖苷，可以从长小苞蔓黄芪的根中分离出。Acetylastragaloside I 是第一个具有显著的锥虫杀灭活性的环阿坦型三萜，对布氏罗得西亚锥虫和美洲锥虫的 IC50 值分别为 9.5 和 5.0 μg/mL。Acetylastragaloside I 可用于锥虫感染的研究。

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Acetylastragaloside I Chemical Structure

Acetylastragaloside I Chemical Structure

CAS No. : 84687-47-8

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Acetylastragaloside I 相关抗体

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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  • 参考文献

生物活性

Acetylastragaloside I is a glycoside that can be isolated from the roots of Astragalus baibutensis. Acetylastragaloside I is the first cycloartane-type triterpene with remarkable trypanocidal activity with IC50 values of 9.5 and 5.0 μg/mL for T. brucei rhodesiense and T. cruzi, respectively. Acetylastragaloside I can be used for the research of trypanosome infection[1].

IC50 & Target

IC50: 9.5 μg/mL (T. brucei rhodesiense), 5.0 μg/mL (T. cruzi), ＞30 μg/mL (L. donovani), ＞20 μg/mL (P. falciparum), 24.2 μg/mL (L6 cells)[1]
体外研究
(In Vitro)

Acetylastragaloside I (0.123-90 μg/mL; 72-96 h) shows in vitro antiprotozoal activity to T. brucei rhodesiense, T. cruzi, L. donovani and P. falciparum with IC50 values of 9.5, 5.0, ＞30 and ＞20 μg/mL, respectively[1].
Acetylastragaloside I (0.123-90 μg/mL; 72 h) exhibits cytotoxicity effects to rat skeletal myoblasts (L6) cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Acetylastragaloside I 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: Rat skeletal myoblasts (L6) cell line
Concentration: 0.123-90 μg/mL
Incubation Time: 72 hours
Result: Showed cytotoxicity to L6 cells with an IC50 value of 24.2 μg/mL.
分子量

911.08

Formula

C47H74O17
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Acetylastragaloside I 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Acetylastragaloside I84687-47-8ParasiteglycosideAstragalus baibutensistriterpenetrypanocidaltrypanosomeinfectionInhibitorinhibitorinhibit

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