2. Anti-infection Apoptosis Cell Cycle/DNA Damage
  3. Influenza Virus Orthopoxvirus SARS-CoV Apoptosis CDK Bcl-2 Family
  4. Amantadine sulfate

Amantadine sulfate  (Synonyms: 1-Adamantanamine sulfate; 1-Aminoadamantane sulfate)

目录号: HY-B0402B
产品使用指南

摩尔计算器

Amantadine (1-Adamantanamine) sulfate 是一种口服有效的抗甲型流感 (influenza A) 病毒的抗病毒剂。Amantadine sulfate 对 NMDA、M2 等多种离子通道均有抑制作用。Amantadine sulfate 还具有抗正痘病毒 (orthopoxvirus) 和抗癌活性。Amantadine sulfate 可用于帕金森病，术后认知功能障碍 (POCD) 和 COVID-19 的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Amantadine sulfate Chemical Structure

Amantadine sulfate Chemical Structure

CAS No. : 31377-23-8

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Amantadine sulfate 的其他形式现货产品:

Customer Review

Other Forms of Amantadine sulfate:

Amantadine sulfate 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Amantadine (1-Adamantanamine) sulfate is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine sulfate inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine sulfate also has anti-orthopoxvirus and anticancer activity. Amantadine sulfate can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research[1][2][3][4][5][6].

IC50 & Target

CDK2

 

Bcl-2

 

Bax

 

体外研究
(In Vitro)

Amantadine sulfate (0-500 µM, 26 h) inhibits SARS-CoV-2 replication, with IC50 concentrations between 83 and 119 µM[4].
Amantadine sulfate (0-100 µg/mL, 24-72 h) markedly inhibits the proliferation of HepG2 and SMMC‑7721 cells[6].
Amantadine sulfate (0-75 µg/mL, 48 h) arrests the cell cycle at the G0/G1 phase and induces apoptosis[6].
Amantadine sulfate (0-75 µg/mL, 48 h) reduces the levels of the cell cycle‑related genes and proteins (cyclin D1, cyclin E and CDK2), reduces Bcl-2 and increases the Bax protein and mRNA levels[6].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Amantadine sulfate 相关抗体:

Cell Viability Assay[4]

Cell Line: Vero E6 cells
Concentration: 500 µM, 100 µM, 20 µM, 4 µM, and 8 nM
Incubation Time: 26 h
Result: Caused a concentration-dependent reduction (IC50=83 µM) of viral nucleic acids in the supernatant 26 h after infection at 10-500 µM. Caused a concentration-dependent reduction (IC50=119 µM) of viral nucleic acids in the cytosol 26 h after infection.

Cell Proliferation Assay[6]

Cell Line: Human HCC cell lines (HepG2 and SMMC-7721) and normal hepatocellular cells (L02 cells)
Concentration: 0, 1, 2, 5, 10, 25, 50 and 100 µg/mL
Incubation Time: 24, 48 and 72 h
Result: Inhibited cellular proliferation in a time- and dose-dependent manner in HepG2 and SMMC-7721 cells.

Cell Cycle Analysis[6]

Cell Line: HepG2 and SMMC-7721 cells
Concentration: 0, 10, 25, 50 and 75 µg/mL
Incubation Time: 48 h
Result: Significantly increased the population of HepG2 and SMMC-7721 cells in the G0/G1 phase in a dose-dependent manner, and significantly decreased the number of HepG2 cells in the S phase.

Apoptosis Analysis[6]

Cell Line: HepG2 and SMMC-7721 cells
Concentration: 0, 10, 25, 50 and 75 µg/mL
Incubation Time: 48 h
Result: Markedly increased the percentage of apoptotic HepG2 and SMMC-7721 cells (early- and late-stage apoptosis) in a dose-dependent manner.

Western Blot Analysis[6]

Cell Line: HepG2 and SMMC-7721 cells
Concentration: 0, 10, 25, 50 and 75 µg/mL
Incubation Time: 48 h
Result: Showed downregulation of cyclin D1, cyclin E and CDK2, and showed a decrease in Bcl-2 levels and an increase of Bax levels in HepG2 and SMMC-7721 cells.

RT-PCR[6]

Cell Line: HepG2 and SMMC-7721 cells
Concentration: 0, 10, 25, 50 and 75 µg/mL
Incubation Time: 48 h
Result: Revealed an increase in Bax and decrease in Bcl-2 genes.
体内研究
(In Vivo)

Amantadine sulfate (25 mg/kg, IP, once daily for 3 days) inhibits surgery induced neuroinflammation and learning and memory impairment[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fischer 344 rats (Four-month old, male, 290-330 g, 15 rats each group)[5]
Dosage: 25 mg/kg
Administration: IP, once daily for 3 days (the first dose at 15 min before surgery)
Result: Inhibited surgery induced neuroinflammation and learning and memory impairment, increased GDNF (glial cell line-derived neurotrophic factor) that was co-localized with glial fibrillary acidic protein (an astrocytic marker) in the hippocampus.
Clinical Trial
分子量

200.18

Formula

C10H17N.1/2H2O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Amantadine sulfate 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amantadine31377-23-81-Adamantanamine1-AminoadamantaneInfluenza VirusOrthopoxvirusSARS-CoVApoptosisCDKBcl-2 FamilySARS coronavirusCyclin dependent kinaseM2 proton channelantiviralParkinson's diseaseVero E6 cellsantiviral drugsCovid-19SARS-CoV-2orthopoxvirusmemory impairmentPostoperative cognitive dysfunctionPOCDNeuroinflammationHCC cellsHepG2SMMC?7721hepatitis C virusanticancerliver cancerInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Amantadine sulfate
目录号：
HY-B0402B
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z