Anti-MHC Class I Antibody (W6/32) 

Anti-MHC Class I Antibody (W6/32) is a kind of mouse IgG2a κ chimeric antibody inhibitor, targeting to human MHC Class I. Anti-MHC Class I Antibody (W6/32) reacts with the human major histocompatibility complex (MHC) class I, HLA-A, B, and C. Anti-MHC Class I Antibody (W6/32) increases adherence of monocytes to human endothelial cells. Anti-MHC Class I Antibody (W6/32) can be used for the research of immunology^[1][2].

Mouse IgG2a kappa

Mouse IgG2a kappa, Isotype Control

Human

MHC Class I

Anti-MHC Class I Antibody (W6/32) (5 μg/mL, 1 h) 显著增加了人主动脉内皮细胞中血管性血友病因子的分泌和单核细胞黏附^[1]。
Anti-MHC Class I Antibody (W6/32) (1 μg/mL, 30 mins) 通过 Mac-1/ICAM-1 相互作用增加了人内皮单层中黏附的 Mono Mac 6 细胞数量^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA, FACS, Functional assay, Research in vivo

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

液体

Colorless to light yellow

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Valenzuela NM, et al. Blockade of p-selectin is sufficient to reduce MHC I antibody-elicited monocyte recruitment in vitro and in vivo. Am J Transplant. 2013 Feb;13(2):299-311.  [Content Brief]

  [2]. Valenzuela et al. HLA class I antibodies trigger increased adherence of monocytes to endothelial cells by eliciting an increase in endothelial P-selectin and, depending on subclass, by engaging FcγRs. J Immunol. 2013 Jun 15;190(12):6635-50.  [Content Brief]