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  4. Anti-Mouse/Human CD11b Antibody (M1/70)

Anti-Mouse/Human CD11b Antibody (M1/70) 

目录号: HY-P99121 纯度: 95.00%
COA 技术支持

Anti-Mouse/Human CD11b Antibody (M1/70) 是一种抗小鼠 CD11b IgG2b 单克隆抗体。Anti-Mouse/Human CD11b Antibody (M1/70) 可以显著抑制树突状细胞 (DC) 和血小板之间的粘附。Anti-Mouse/Human CD11b Antibody (M1/70) 可以杀伤卵巢癌细胞并且抑制其迁移。Anti-Mouse/Human CD11b Antibody (M1/70) 可以缓解肾纤维化和炎症。Anti-Mouse/Human CD11b Antibody (M1/70) 可用于研究炎症疾病和癌症，如缺血再灌注损伤 (IRI)，血栓性炎症疾病和卵巢癌。

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Anti-Mouse/Human CD11b Antibody (M1/70)

Anti-Mouse/Human CD11b Antibody (M1/70) Chemical Structure

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规格 价格 是否有货 数量
1 mg ￥2200
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5 mg ￥6500
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10 mg ￥10400
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Anti-Mouse/Human CD11b Antibody (M1/70) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse/Human CD11b Antibody (M1/70) is an anti-mouse CD11b IgG2b monoclonal antibody. Anti-Mouse/Human CD11b Antibody (M1/70) can significantly inhibit the adhesion between dendritic cells (DCs) and platelets. Anti-Mouse/Human CD11b Antibody (M1/70) can kill ovarian cancer cells and inhibit their migration. Anti-Mouse/Human CD11b Antibody (M1/70) can alleviate renal fibrosis and inflammation. Anti-Mouse/Human CD11b Antibody (M1/70) can be used for researches on inflammation conditions and cancer such as ischemia-reperfusion injury (IRI), thrombotic inflammatory conditions and ovarian cancer[1][2][3].

同型

Rat IgG2b kappa
推荐同型对照抗体
反应种属

Mouse
体外研究
(In Vitro)

Anti-Mouse/Human CD11b Antibody (M1/70) (10 μg/mL，30 分钟) 显著抑制骨髓来源的树突状细胞 (bmDCs) 与固定血小板的粘附[2]。
Anti-Mouse/Human CD11b Antibody (M1/70) (5-10 μg/mL，24 小时) 显著杀死上皮性卵巢癌症 (EOC) 细胞[3]。
Anti-Mouse/Human CD11b Antibody (M1/70) (5-15 μg/mL，36 小时) 剂量依赖性地抑制 SKOV-3 和 MDAH-2774 细胞中的细胞迁移[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse/Human CD11b Antibody (M1/70) 相关抗体:

Cell Viability Assay[3]

Cell Line: A2780, MDAH-2774, SKOV-3, OV90, TOV-21G, TOV112D and OV433 cells
Concentration: 5 and 10 μg/mL
Incubation Time: 24 h
Result: Significantly killed EOC cells with various efficacies ranging from 27 % to 96 %.

Cell Migration Assay [3]

Cell Line: SKOV-3 and MDAH-2774 cells
Concentration: 5, 10 and 15 μg/mL
Incubation Time: 36 h
Result: Delayed closure until 28 hours at 10 μg/mL, inhibited 50 % migration at 15 μg/mL.
体内研究
(In Vivo)

Anti-Mouse/Human CD11b Antibody (M1/70) (2.5 mg/kg，腹腔注射，每 2 天一次，持续 14 天) 显著降低了具有缺血再灌注损伤 (IRI) 的雄性 C57BL/6J 小鼠的肾纤维化和炎症[1]。
Anti-Mouse/Human CD11b Antibody (M1/70) (50 μg，静脉注射，单剂量) 在颈动脉结扎模型的野生型 C57BL/6 小鼠中显著抑制 DC 细胞与受损血管的粘附[2]。
Anti-Mouse/Human CD11b Antibody (M1/70) (60 μg，瘤内注射，每天一次，持续 5 天) 显著抑制携带 SKOV-3 肿瘤的雌性人胸腺 Nude-Oxn1nu 小鼠的肿瘤生长[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice (6-8 weeks) with an IRI model[1]
Dosage: 2.5 mg/kg
Administration: Intraperitoneal injection (i.p.), once every 2 days for 14 days
Result: Improved renal fibrosis.
Reduced the the level of Col1a1, Fn1, α-SMA and Col3a1.
Improved the pathological progression of severe acute kidney injury (AKI) to chronic kidney disease (CKD).
Animal Model: Wild type C57BL/6 mice with a carotid artery ligation model[2]
Dosage: 50 μg
Administration: Intravenous injection (i.v.), single dose
Result: Significantly inhibited the adhesion of DCs to damaged blood vessels.
Animal Model: 1.5×106 SKOV-3 cells injected female anthymic Nude-Foxn1nu mice[3]
Dosage: 60 μg
Administration: Intratumoral injection, once daily for 5 days
Result: Reduced tumor volume by 47 % on day 2, reduced tumor volume by 64.9 % on day 4 and reduced tumor volume by 59.7 % on day 5.
Had no significant systemic toxicity.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-Mouse/Human CD11b Antibody (M1/70) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse/Human CD11b Antibody (M1/70)IntegrinCD11bplateletsDCIRIinflammationSKOV-3EOCInhibitorinhibitorinhibit

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Anti-Mouse/Human CD11b Antibody (M1/70)
目录号：
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