2. Immunology/Inflammation Anti-infection
  3. MHC Influenza Virus
  4. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114)

Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) 

目录号: HY-P990187
技术支持

Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) 是一种大鼠源性 IgG2b 型抗体抑制剂，靶向小鼠 MHC Class II。Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) 与小鼠 MHC II 类单倍型 I-Ab、I-Ad、I-Aq、I-Ed 和 I-Ek 发生反应。Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) 不与 I-Af、I-Ak 或 I-As 单倍型发生反应。Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) 可阻断 MHC II 类并抑制 T 细胞生成。Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) 可用于感染与免疫学的研究，如甲型流感病毒 (IAV) 感染。

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Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114)

Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) Chemical Structure

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) is a rat-derived IgG2b type antibody inhibitor, targeting to mouse MHC Class II. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) reacts with mouse MHC Class II haplotypes I-Ab, I-Ad, I-Aq, I-Ed, and I-Ek. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) does not react with I-Af, I-Ak, or I-As haplotypes. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) blocks MHC Class II and inhibit T cell generation. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) can be used for the researches of infection and immunology, such as influenza A virus (IAV) infection[1].

同型

Rat IgG2b
推荐同型对照抗体
反应种属

Mouse
体外研究
(In Vitro)

抗体框架具有稳定性、特异性和适应性，同时具有结合抗原和内源免疫受体。 单克隆抗体具有几种衍生物，包括双特异性抗体、抗体-药物缀合物和抗体片段，在免疫学和肿瘤学等领域具有显著效果。 设计抑制性抗体时，需要注意包括抗原特异性可变区的鉴定、表达系统的选择、多特异性形式的使用以及基于片段化、寡聚化或与其他功能部分缀合的抗体衍生物[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) (1 mg/day，静脉注射，第 4 天至第 6 天) 可减少甲型流感病毒 (IAV) 感染小鼠中记忆性 CD4 T 细胞的生成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Influenza A virus (IAV)-infected mice[1]
Dosage: 1 mg/day
Administration: Intravenously injection, from day 4 to 6
Result: Reduced primary effector expansion in the lung.
Dramatically reduced donor cell recovery at day 28 in recipients of naive and primed cells.
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114)MHCInfluenza VirusMajor Histocompatibility ComplexMHC Class III-AbI-AdI-AqI-Edand I-EkT cellsInfluenza A virusInhibitorinhibitorinhibit

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