2. Anti-infection
  3. Bacterial
  4. Antibacterial agent 98

Antibacterial agent 98 (compound g37) 是一种有效的口服活性抗菌剂。Antibacterial agent 98 抑制 Gyrase B 的 ATP 酶活性并削弱 金黄色葡萄球菌 (S. aureus ) 的DNA 超螺旋。Antibacterial agent 98 具有抗菌活性，并且不会诱导 MRSA (耐甲氧西林 金黄色葡萄球菌 (S. aureus)) 的耐药性发展。

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Antibacterial agent 98 Chemical Structure

Antibacterial agent 98 Chemical Structure

CAS No. : 2408695-41-8

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Antibacterial agent 98 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antibacterial agent 98 (compound g37) is a potent and orally active antibacterial agent. Antibacterial agent 98 inhibits the ATPase activity of Gyrase B and impairs Staphylococcus aureus (S. aureus ) DNA supercoiling. Antibacterial agent 98 shows antibacterial activity and not induce resistance development of MRSA (methicillin-resistant S. aureus)[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HepG2 IC50
55.3 μM
Compound: g37
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by sulforhodamine B assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by sulforhodamine B assay
[PMID: 31901744]
HUVEC IC50
38.8 μM
Compound: g37
Cytotoxicity against HUVEC assessed as reduction in cell viability after 72 hrs by sulforhodamine B assay
Cytotoxicity against HUVEC assessed as reduction in cell viability after 72 hrs by sulforhodamine B assay
[PMID: 31901744]
体外研究
(In Vitro)

Antibacterial agent 98 (compound g37) shows antibacterial activity with an NICs of 0.1 μg/mL for S. aureus ATCC29213 and an IC50 of 0.15 µM for GyrB[1].
Antibacterial agent 98 shows cytotoxicity with IC50s of 55.3, 38.8 µM for HepG2, HUVEC cells, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 98 相关抗体:
分子量

399.45

Formula

C17H13N5O3S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antibacterial agent 98 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antibacterial agent 982408695-41-8Antibacterial agent98Antibacterial agent-98BacterialS. aureus ATCC29213HepG2HUVEC cellsorally activeantibacterialDNA supercoilingGyrase BInhibitorinhibitorinhibit

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