2. Apoptosis
  3. Apoptosis
  4. Beta-Zearalanol

Beta-Zearalanol  (Synonyms: β-玉米赤霉醇)

目录号: HY-N6740 纯度: 99.83%
COA 产品使用指南 技术支持

Beta-Zearalanol 是由镰刀菌属 Fusarium 产生的一种霉菌毒素，可以在哺乳动物生殖细胞中引起细胞凋亡 (apoptosis) 和氧化应激反应。 Beta-Zearalanol 是玉米赤霉烯酮（ZEA）的衍生物，可以与葡萄糖醛酸 (glucuronic acid) 结合。

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Beta-Zearalanol Chemical Structure

Beta-Zearalanol Chemical Structure

CAS No. : 42422-68-4

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1760
In-stock
5 mg ￥1600
In-stock
10 mg ￥2600
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

Other Forms of Beta-Zearalanol:

Beta-Zearalanol 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Beta-Zearalenol is an mycotoxin produced by Fusarium spp, which causes apoptosis and oxidative stress in mammalian reproductive cells[1]. Beta-Zearalenol is the derivative of zearalenone (ZEA) which can conjugate with glucuronic acid[2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MCF7 IC50
> 25 μM
Compound: 10
Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay
[PMID: 21513293]
MCF7 IC50
> 25 μM
Compound: 12
Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay
[PMID: 21513293]
NCI-H460 IC50
15.4 μM
Compound: 10
Cytotoxicity against human H460 cells after 72 hrs by MTS assay
Cytotoxicity against human H460 cells after 72 hrs by MTS assay
[PMID: 21513293]
NCI-H460 IC50
9.5 μM
Compound: 12
Cytotoxicity against human H460 cells after 72 hrs by MTS assay
Cytotoxicity against human H460 cells after 72 hrs by MTS assay
[PMID: 21513293]
SF-268 IC50
> 25 μM
Compound: 12
Cytotoxicity against human SF268 cells after 72 hrs by MTS assay
Cytotoxicity against human SF268 cells after 72 hrs by MTS assay
[PMID: 21513293]
SF-268 IC50
> 50 μM
Compound: 10
Cytotoxicity against human SF268 cells after 72 hrs by MTS assay
Cytotoxicity against human SF268 cells after 72 hrs by MTS assay
[PMID: 21513293]
Vero IC50
1.5 μM
Compound: 17
Antiviral activity against HSV1 F infected in african green monkey Vero cells assessed as reduction of virus-induced cytopathic effect by cellular replication assay
Antiviral activity against HSV1 F infected in african green monkey Vero cells assessed as reduction of virus-induced cytopathic effect by cellular replication assay
[PMID: 12828470]
Vero IC50
15 μM
Compound: 21
Antiviral activity against HSV1 F infected in african green monkey Vero cells assessed as reduction of virus-induced cytopathic effect by cellular replication assay
Antiviral activity against HSV1 F infected in african green monkey Vero cells assessed as reduction of virus-induced cytopathic effect by cellular replication assay
[PMID: 12828470]
Vero IC50
22.61 μM
Compound: 3
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by green fluorescent protein-based assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by green fluorescent protein-based assay
[PMID: 27311894]
体外研究
(In Vitro)

βeta-Zearalenol (0-200 μM；24 小时) 以剂量依赖性方式抑制 BGC 增殖，IC50 为 25 μM[1]。
βeta-Zearalenol (0-100 μM；72 hours) 在 HepG2 细胞中表现出高毒性，IC50 为 15.2 μM，与 与 β-ZOL+ZEN 或 β-ZOL+α-ZOL 有协同作用， IC50 值分别为 19.8 uM、16.8 uM[2]。
βeta-Zearalenol (0-10 μM；72 hours) 对所研究的所有三种细胞因子均具有最高的抑制作用：IL-8、IL-1β 和TNF-α 与 ZEA 或 α-Zearalenol 进行比较[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Beta-Zearalanol 相关抗体:

Cell Viability Assay[2]

Cell Line: HepG2 cells
Concentration: 0-100 μM
Incubation Time: 72 hours
Result: Shown a dose-dependent reduction of viability of cells treated with Beta-Zearalanol.

Cell Proliferation Assay[1]

Cell Line: BGC cells
Concentration: 0 μM, 5 μM, 10 μM, 15 μM, 25 μM, 50 μM, 100 μM, and 200 μM
Incubation Time: 24 hours
Result: Inhibited cell proliferation in a dose-dependent manner.

RT-PCR[2]

Cell Line: HepG2 cells
Concentration: 1 μM, 5 μM, 10 μM
Incubation Time: 72 hours
Result: Had the higher cytotoxic effect in comparation with α-Zearalenol.
分子量

322.40

Formula

C18H26O5
CAS 号
性状

固体

颜色

White to off-white

中文名称

β-玉米赤霉醇
结构分类
初始来源

Fusarium species
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (310.17 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.1017 mL 15.5087 mL 31.0174 mL
5 mM 0.6203 mL 3.1017 mL 6.2035 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.83%

COA (286 KB) LCMS (270 KB)

产品使用指南 (1538 KB)
参考文献

Beta-Zearalanol 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1017 mL 15.5087 mL 31.0174 mL 77.5434 mL
5 mM 0.6203 mL 3.1017 mL 6.2035 mL 15.5087 mL
10 mM 0.3102 mL 1.5509 mL 3.1017 mL 7.7543 mL
15 mM 0.2068 mL 1.0339 mL 2.0678 mL 5.1696 mL
20 mM 0.1551 mL 0.7754 mL 1.5509 mL 3.8772 mL
25 mM 0.1241 mL 0.6203 mL 1.2407 mL 3.1017 mL
30 mM 0.1034 mL 0.5170 mL 1.0339 mL 2.5848 mL
40 mM 0.0775 mL 0.3877 mL 0.7754 mL 1.9386 mL
50 mM 0.0620 mL 0.3102 mL 0.6203 mL 1.5509 mL
60 mM 0.0517 mL 0.2585 mL 0.5170 mL 1.2924 mL
80 mM 0.0388 mL 0.1939 mL 0.3877 mL 0.9693 mL
100 mM 0.0310 mL 0.1551 mL 0.3102 mL 0.7754 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Beta-Zearalanol42422-68-4β-玉米赤霉醇ApoptosisInhibitorinhibitorinhibit

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