2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK1-IN-3

CDK1-IN-3 (8g) 是 CDK1 的选择性抑制剂，对 CDK1，CDK2 和 CDK5 的 IC50 值分别为 36.8，305.17 和 369.37 nM。CDK1-IN-3 通过影响细胞周期抑制癌细胞的生长。CDK1-IN-3 可用于癌症的研究。

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CDK1-IN-3 Chemical Structure

CDK1-IN-3 Chemical Structure

CAS No. : 3032997-12-6

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CDK1-IN-3 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CDK1-IN-3 (8g) is a selective CDK1 inhibitor with IC50s of 36.8, 305.17 and 369.37 nM for CDK1, CDK2 and CDK5, respectively. CDK1-IN-3 inhibits the growth of cancer cells by affecting cell cycle. CDK1-IN-3 can be used for the research of cancer[1].

IC50 & Target

CDK1

36.8 nM (IC50)

CDK2

305.17 nM (IC50)

CDK5

369.37 nM (IC50)

体外研究
(In Vitro)

CDK1-IN-3 (0-10 μM; 24 h) inhibits the growth of PDAC, melanoma, leukemia, colon and breast cancer cells[1].
CDK1-IN-3 (0-1 μM) inhibits CDK1, CDK2 and CDK5 with IC50s of 36.8, 305.17 and 369.37 nM, respectively[1].
CDK1-IN-3 (0-10 μM) inhibits AXL, PTK2B, FGFR, JAK1, IGF1R and BRAF kinases with IC50s of 5655, 3632, 4626, 5265, 5514 and 2829 nM, respectively[1].
CDK1-IN-3 (0.51 μM; 24 h) decreases CDK1 protein level in virto and affects cell cycle[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CDK1-IN-3 相关抗体:

Cell Proliferation Assay[1]

Cell Line: PDAC, melanoma, leukemia, colon and breast cancer cell lines
Concentration: 0-10 μM
Incubation Time: 24 hours
Result: Inhibited cell growth of PDAC, melanoma, leukemia, colon, and breast cancer cells over 61%, and inhibited MDA-PATC53 and PL45 cells with IC50s of 0.51 and 0.74 μM, respectively.

Western Blot Analysis[1]

Cell Line: MDA-PATC53 cell line
Concentration: 0.51 μM
Incubation Time: 24 hours
Result: Downregulated CDK1 protein level compared to untreated cells.

Western Blot Analysis[1]

Cell Line: MDA-PATC53 cell line
Concentration: 0.51 μM
Incubation Time: 24 hours
Result: Significantly arrested in G2/M phase of the cell cycle compared with the untreated cells.
分子量

555.98

Formula

C28H25ClF3N5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CDK1-IN-3 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK1-IN-33032997-12-6CDKCyclin dependent kinasephthalazineanticancerpancreaticderivativecell cyclePDACmelanomaleukemiacolonbreastcancerMDA-PATC53Inhibitorinhibitorinhibit

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