Cefixime trihydrate  (Synonyms: 头孢克肟水合物; FR-17027 trihydrate; FK-027 trihydrate; CL-284635 trihydrate)

Cefixime trihydrate (FR-17027 trihydrate) is an antibiotic and a third generation cephalosporin antibiotic, useful for the treatment of a number of bacterial infections^[1][2].

Cefixime 对临床分离的伤寒沙门氏菌具有良好的抗菌活性，MIC90 值为 0.25 μg/mL，并且对产生 β-内酰胺酶的 Amoxicillin (HY-B0467A) 耐药菌株也具有活性 ^[3]。
Cefixime 还对肠杆菌科细菌有活性，例如流感嗜血杆菌和淋病奈瑟菌^[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cefixime (0.75-60 mg/kg，口服灌胃) trihydrate 可减少接受 FA1090 (ESC 敏感菌株) 攻击的小鼠的细菌负荷^[4]。
Cefixime (50 或 150 mg/kg，口服灌胃) trihydrate 改变了 C57BL/6J 小鼠肠道微生物群的结构和丰度，具体而言，减少了微生物群落的多样性，并减少到一种厚壁菌门^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

507.50

C₁₆H₂₁N₅O₁₀S₂

125110-14-7

固体

White to off-white

头孢克肟水合物；世伏素水合物

Room temperature in continental US; may vary elsewhere.

• [1]. Neu HC, et al. In vitro activity of a new broad spectrum, beta-lactamase-stable oral cephalosporin, cefixime. Pediatr Infect Dis J. 1987 Oct;6(10):958-62.  [Content Brief]

  [2]. Unemo M, et al. High-level cefixime- and ceftriaxone-resistant Neisseria gonorrhoeae in France: novel penA mosaic allele in a successful international clone causes treatment failure. Antimicrob Agents Chemother. 2012 Mar;56(3):1273-80.  [Content Brief]

  [3]. Matsumoto Y, et al. Antibacterial activity of cefixime against Salmonella typhi and applicability of Etest. J Infect Chemother. 1999 Sep;5(3):176-179.  [Content Brief]

  [4]. Connolly KL, et al. Pharmacokinetic Data Are Predictive of In Vivo Efficacy for Cefixime and Ceftriaxone against Susceptible and Resistant Neisseria gonorrhoeae Strains in the Gonorrhea Mouse Model. Antimicrob Agents Chemother. 2019 Feb 26;63(3):e01644-18.  [Content Brief]

  [5]. Shi Y, et al. Restoration of cefixime-induced gut microbiota changes by Lactobacillus cocktails and fructooligosaccharides in a mouse model. Microbiol Res. 2017 Jul;200:14-24.  [Content Brief]

  [6]. Stone JW, et al. Cefixime, in-vitro activity, pharmacokinetics and tissue penetration. J Antimicrob Chemother. 1989 Feb;23(2):221-8.  [Content Brief]