2. Metabolic Enzyme/Protease
  3. Angiotensin-converting Enzyme (ACE)
  4. CL-242817

CL-242817 是一种口服有效的血管紧张素转换酶 (ACE) 抑制剂。CL-242817 抑制血管紧张素 I 转换为血管紧张素 II 的过程，有降低血压的活性。CL-242817 还能改善 Monocrotaline (HY-N0750) 引起的肺损伤。CL-242817 可用于肺纤维化和高血压相关疾病的研究。

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CL-242817 Chemical Structure

CL-242817 Chemical Structure

CAS No. : 86709-48-0

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CL-242817 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CL-242817 is an orally available angiotensin converting enzyme (ACE) inhibitor. CL-242817 inhibits the conversion of angiotensin I to angiotensin II and has blood pressure lowering activity. CL-242817 can also improve Monocrotaline (HY-N0750) induced lung injury. CL-242817 can be used in the study of pulmonary fibrosis and hypertension-related diseases[1].

体外研究
(In Vitro)

CL-242817 在体外有效抑制兔肺 ACE (IC50=54.9 nM)、血管紧张素I (Al) 诱导的离体豚鼠回肠的收缩 (IC50=0.82 pM)，增强豚鼠回肠缓激素 (BK) 诱导的离体豚鼠回肠的收缩 (EC50=0.383 pM)[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CL-242817 相关抗体:
体内研究
(In Vivo)

CL-242817 (60 mg/kg, p.o., 每天一次, 持续六周) 给药的雄性 Wistar 大鼠相比于对照组未能以正常速度增重且心脏功能降低，显著改善了 Monocrotaline (HY-N0750) 造成的血管闭塞和单胆碱损伤，并抑制 ACE 活性以及降低肺中羟脯氨酸 (HP) 含量[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

363.43

Formula

C18H21NO5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CL-242817 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CL-24281786709-48-0CL242817CL 242817Angiotensin-converting Enzyme (ACE)ACEblood pressurelung injurypulmonary fibrosismale Wistar ratsInhibitorinhibitorinhibit

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