2. Metabolic Enzyme/Protease
  3. Mitochondrial Metabolism
  4. COQ7-IN-1

COQ7-IN-1 是一种高效的人辅酶 Q (COQ7) 抑制剂，可干扰泛醌 (UQ) 合成。COQ7-IN-1 不会干扰正常培养细胞生长。COQ7-IN-1 可用于研究 UQ 补充途径 (从头合成 UQ 和胞外摄取 UQ) 之间的平衡。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

COQ7-IN-1 Chemical Structure

COQ7-IN-1 Chemical Structure

CAS No. : 2579696-72-1

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥1100
In-stock
5 mg ￥1000
In-stock
10 mg ￥1700
In-stock
25 mg ￥3500
In-stock
50 mg ￥5500
In-stock
100 mg 现货 询价
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

COQ7-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

COQ7-IN-1, a highly potent inhibitor of human coenzyme Q (COQ7), interferes with ubiquinone (UQ) synthesis. COQ7-IN-1 does not disturb physiological cell growth of human normal culture cells. COQ7-IN-1 can be used for the research of the balance between UQ supplementation pathways: de novo UQ synthesis and extracellular UQ uptake[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
C3A GI50
6.1 μM
Compound: 8
Growth inhibition of human C3A cells after 3 days in presence of 10 mM 2-DG by cell-titer-Glo assay
Growth inhibition of human C3A cells after 3 days in presence of 10 mM 2-DG by cell-titer-Glo assay
[PMID: 31753803]
C3A GI50
9 μM
Compound: 8
Growth inhibition of human C3A cells assessed as growth inhibition after 3 days by cell-titer-Glo assay
Growth inhibition of human C3A cells assessed as growth inhibition after 3 days by cell-titer-Glo assay
[PMID: 31753803]
HeLa GI50
> 12 μM
Compound: 8
Growth inhibition of human HeLa cells assessed as growth inhibition after 3 days by cell-titer-Glo assay
Growth inhibition of human HeLa cells assessed as growth inhibition after 3 days by cell-titer-Glo assay
[PMID: 31753803]
PANC-1 GI50
> 12 μM
Compound: 8
Growth inhibition of human PANC1 cells after 3 days by cell-titer-Glo assay
Growth inhibition of human PANC1 cells after 3 days by cell-titer-Glo assay
[PMID: 31753803]
PC-3 GI50
> 12 μM
Compound: 8
Cytotoxicity against human PC3 cells assessed as growth inhibition after 3 days by cell-titer-Glo assay
Cytotoxicity against human PC3 cells assessed as growth inhibition after 3 days by cell-titer-Glo assay
[PMID: 31753803]
WI-38 GI50
> 12 μM
Compound: 8
Cytotoxicity against human WI38 cells assessed as growth inhibition after 4 days by cell-titer-Glo assay
Cytotoxicity against human WI38 cells assessed as growth inhibition after 4 days by cell-titer-Glo assay
[PMID: 31753803]
WI-38 GI50
19 μM
Compound: 8
Cytotoxicity against human WI38 cells assessed as growth inhibition after 4 days by cell-titer-Glo assay
Cytotoxicity against human WI38 cells assessed as growth inhibition after 4 days by cell-titer-Glo assay
[PMID: 31753803]
体外研究
(In Vitro)

COQ7-IN-1 (Compound 8; 0-30 μM; for 4 days) inhibits WI-38 cells growth with a GI50 of 19.0 μM. COQ7-IN-1 weakly inhibits C3A cells growth with GI50 of 9.0±1.1 μM. COQ7-IN-1 does not limit C3A cell survival through inhibiting aerobic respiration or increasing oxidative stress[1].
COQ7 converts demethoxy-UQ (DMQ) to demethyl-UQ (DMeQ), and then converted to UQ by COQ3. Cells under COQ7 deficiency are unable to produce UQ, and consequently accumulate DMQ. DMQ10 and UQ10 contents in each culture well are 13.2 and 12.2 ng/well for COQ7-IN-1 (10 μM; for 2 days) cultured with HeLa cells. DMQ10 content of COQ7-IN-1 in HeLa cells is 52.0%[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

COQ7-IN-1 相关抗体:

Cell Viability Assay[1]

Cell Line: WI-38 cells
Concentration: 0-30 μM
Incubation Time: 4 days
Result: The concentration that caused 50% cell growth inhibition (GI50) was 19.0 μM.
分子量

271.70

Formula

C14H10ClN3O
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (368.05 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.6805 mL 18.4026 mL 36.8053 mL
5 mM 0.7361 mL 3.6805 mL 7.3611 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

请根据您的 实验动物和给药方式 选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 方案 一

    请依序添加每种溶剂： 10% DMSO    90% Corn Oil

    Solubility: ≥ 2.08 mg/mL (7.66 mM); 澄清溶液

    此方案可获得 ≥ 2.08 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
请输入您的动物体内配方组成：
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。
方案所需 助溶剂 包括：DMSO， ，均可在 MCE 网站选购。 ，Tween 80，均可在 MCE 网站选购。
计算结果
工作液所需浓度 : mg/mL
储备液配制方法 : mg 药物溶于 μL  DMSO（母液浓度为 mg/mL）。
您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。
动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。
连续给药周期超过半月以上，请谨慎选择该方案。
请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热 （超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。
纯度 & 产品资料
参考文献

COQ7-IN-1 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6805 mL 18.4026 mL 36.8053 mL 92.0132 mL
5 mM 0.7361 mL 3.6805 mL 7.3611 mL 18.4026 mL
10 mM 0.3681 mL 1.8403 mL 3.6805 mL 9.2013 mL
15 mM 0.2454 mL 1.2268 mL 2.4537 mL 6.1342 mL
20 mM 0.1840 mL 0.9201 mL 1.8403 mL 4.6007 mL
25 mM 0.1472 mL 0.7361 mL 1.4722 mL 3.6805 mL
30 mM 0.1227 mL 0.6134 mL 1.2268 mL 3.0671 mL
40 mM 0.0920 mL 0.4601 mL 0.9201 mL 2.3003 mL
50 mM 0.0736 mL 0.3681 mL 0.7361 mL 1.8403 mL
60 mM 0.0613 mL 0.3067 mL 0.6134 mL 1.5336 mL
80 mM 0.0460 mL 0.2300 mL 0.4601 mL 1.1502 mL
100 mM 0.0368 mL 0.1840 mL 0.3681 mL 0.9201 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COQ7-IN-12579696-72-1Mitochondrial MetabolismCOQ7UbiquinoneUQCoQsynthesis,Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
COQ7-IN-1
目录号：
HY-133033
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z