2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. CP94253

CP94253 是一种口服有效的血清素受体 1B (5-HT1B) 选择性激动剂，通过与碘氰基吲哚洛尔 (ICP) 竞争性结合 5-HT1 受体而发挥激动剂活性。CP94253 与 5-HT1B、5-HT1A、5-HT1D、5-HT1C 和 5-HT2 受体结合，Ki 分别为 2、89、49、860 和 1600 nM。CP94253 在大鼠模型中引起饱腹感、厌食、体重减轻和运动亢进。

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CP94253 Chemical Structure

CP94253 Chemical Structure

CAS No. : 131084-35-0

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100 mg   询价  
250 mg   询价  

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CP94253 的其他形式现货产品:

Customer Review

Other Forms of CP94253:

CP94253 相关抗体

Top Publications Citing Use of Products

查看 5-HT Receptor 亚型特异性产品:

查看所有亚型
5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CP94253 is a selective, orally active agonist for serotonin receptor 1B (5-HT1B), through competitive binding with iodocyanopindolol (ICP) to the 5-HT1 receptor. CP94253 binds to the 5-HT1B, 5-HT1A, 5-HT1D, 5-HT1C and 5-HT2 receptors, with Kis of 2, 89, 49, 860 and 1600 nM. CP94253 causes satiety, anorexia, weight loss and hyperlocomotion in rats model[1].

IC50 & Target

5-HT1B Receptor

2 nM (Ki)

5-HT1D Receptor

49 nM (Ki)

5-HT1A Receptor

89 nM (Ki)

5-HT1C Receptor

860 nM (Ki)

5-HT2 Receptor

1600 nM (Ki)

分子量

257.33

Formula

C15H19N3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CP94253 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CP94253131084-35-0CP 94253CP-942535-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptoranorexiasatietyhyperlocomotionselectiveorally activeSprague Dawley ratInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-103151A
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