2. Protein Tyrosine Kinase/RTK
  3. c-Fms
  4. CSF1R-IN-23

CSF1R-IN-23 (Compound 7dri) 是集落刺激因子 1 受体 (CSF1R) 的选择性抑制剂，IC50 为 36.1 nM。CSF1R-IN-23 在小鼠模型中表现出抗神经炎症活性。CSF1R-IN-23 具有血脑屏障通透性。

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CSF1R-IN-23 Chemical Structure

CSF1R-IN-23 Chemical Structure

CAS No. : 2935480-17-2

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CSF1R-IN-23 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CSF1R-IN-23 (Compound 7dri) is a selective inhibitor for colony-stimulating factor-1 receptor (CSF1R), with IC50 of 36.1 nM. CSF1R-IN-23 serves as antineuroinflammatory agent in mouse model. CSF1R-IN-23 is blood brain barrier (BBB) permeable[1].

体外研究
(In Vitro)

CSF1R-IN-23 (0-10 μM, 30 min) 抑制细胞 RAW264.7 和小胶质细胞 EOC20 中 CSF1R 的自磷酸化，没有明显的细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CSF1R-IN-23 相关抗体:

Western Blot Analysis[1]

Cell Line: EOC20 and RAW264.7
Concentration: 0-10 μM
Incubation Time: 30 min
Result: Inhibited phosphorylation of CSF1R.
体内研究
(In Vivo)

CSF1R-IN-23 (0.5 mg/kg，腹腔注射，每两天一次，共四次)可改善 C57BL/6J 小鼠模型中脂多糖 (HY-D1056) 诱导的神经炎症[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS-induced neuroinflammation in C57BL/6J mice model[1]
Dosage: 0.5 mg/kg
Administration: i.p., every two days for 4 doses
Result: Eliminated the 76% microglias in hippocampus, cortex, and thalamus.
分子量

435.60

Formula

C27H37N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CSF1R-IN-23 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CSF1R-IN-232935480-17-2c-FmsCSF-1 receptorcolony stimulating factor 1 receptorCSF-1RCSF1RAlzheimer’s diseaseneurodegenerative diseasesRAW264.7EOC20BBB permeableC57BL/6J miceInhibitorinhibitorinhibit

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目录号：
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