2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. DDO-02005

DDO-02005 是一种有效的 Kv1.5 钙离子通道抑制剂，IC50 为 0.72 μM。DDO-02005 在 CaCl2-ACh 房颤大鼠模型中具有良好的抗房颤作用，并能有效抵抗乌头碱引起的心律失常。

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DDO-02005 Chemical Structure

DDO-02005 Chemical Structure

CAS No. : 1186049-44-4

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DDO-02005 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DDO-02005 is a potent Kv1.5 potassium channel inhibitor with an IC50 value of 0.72 μM. DDO-02005 has good anti-atrial fibrillation (AF) effect in CaCl2-ACh AF rats model and effective anti-arrhythmic activity caused by aconitine[1].

IC50 & Target

IC50: 0.72 μM (Kv1.5 potassium channel)[1]
体内研究
(In Vivo)

DDO-02005 (0.1, 1, 3, 9 mg/kg; IV, single dosage) effectively combat the arrhythmogenic toxicity of aconitine in rats[1].
Pharmacokinetic Parameters of DDO-02005 in Sprague-Dawley rats[1].

IV (1 mg/kg) PO (1.25 mg/kg)
t1/2 (h) 3.23 ± 1.07 6.25 ± 2.40
Cmax (μg/L) 90.23 ± 28.83 1.27 ± 0.40
AUC0-t (μg/L·h) 178.42 ± 39.33 4.41 ± 0.69
CL (L/h/kg) 5.83 ± 1.44 36.51 ± 2.54

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

424.36

Formula

C21H27Cl2N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DDO-02005 相关分类

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Keywords:

DDO-020051186049-44-4DDO02005DDO 02005Potassium ChannelKcsAKv1.5Anti-arrhythmicAtrial fibrillationSD ratsAconitineInhibitorinhibitorinhibit

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