Deoxymannojirimycin hydrochloride  (Synonyms: 盐酸脱氧甘露霉素)

Deoxymannojirimycin hydrochloride is a selective class I α1,2-mannosidase inhibitor with an IC₅₀ of 20 μM. Deoxymannojirimycin hydrochloride is also a N-linked glycosylation inhibitor. Deoxymannojirimycin hydrochloride has antiviral activity against HIV‐1 strains . Deoxymannojirimycin hydrochloride increases high mannose structures. Deoxymannojirimycin hydrochloride can be used for the study of liver cancer and colon cancer^{[1][2][3][4][5][6]}.

Deoxymannojirimycin (2 mM; 24 h) hydrochloride 可抑制高尔基体 α-甘露糖苷酶 I，并导致 P815 和 EL-4 细胞中高甘露糖结构增加^[1]。
Deoxymannojirimycin (4-5 天) hydrochloride 在 CEM 细胞培养中显示出对抗突变型 HIV-1 毒株的抗病毒功效，EC₅₀ 值在 90 至 155 μM 之间^[2]。
Deoxymannojirimycin (100-250 μM) hydrochloride 可增强 CBA (HHA 和 GNA) 在 CEM 细胞培养中对抗野生型 HIV-1 复制的抗病毒功效^[2]。
Deoxymannojirimycin (1 mM; 8 h) hydrochloride 在人肝癌 7721 细胞中可诱导内质网应激-UPR 关键分子例如 GRP78/Bip 和 XBP1 的激活和上调^[3]。
Deoxymannojirimycin (150 μM; 15 h) hydrochloride 在 UT-1 细胞中导致 Man8GlcNAc2 在 97 kDa HMG-CoA 还原酶上积累^[4]。
Deoxymannojirimycin (2 mM) hydrochloride 完全抑制分化和未分化 HT-29 细胞中的 α-甘露糖苷酶 I 活性^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

163.17

C₆H₁₃NO₄

84444-90-6

盐酸脱氧甘露霉素

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Bagriaçik EU, et al. Glycosylation of native MHC class Ia molecules is required for recognition by allogeneic cytotoxic T lymphocytes. Glycobiology. 1996 Jun;6(4):413-21.  [Content Brief]

  [2]. Balzarini J. The alpha(1,2)-mannosidase I inhibitor Deoxymannojirimycin potentiates the antiviral activity of carbohydrate-binding agents against wild-type and mutant HIV-1 strains containing glycan deletions in gp120. FEBS Lett. 2007 May 15;581(10):2060-4.  [Content Brief]

  [3]. Lu Y, et al. Deoxymannojirimycin, the alpha1,2-mannosidase inhibitor, induced cellular endoplasmic reticulum stress in human hepatocarcinoma cell 7721. Biochem Biophys Res Commun. 2006 May 26;344(1):221-5.  [Content Brief]

  [4]. Bischoff J, et al. The use of Deoxymannojirimycin to evaluate the role of various alpha-mannosidases in oligosaccharide processing in intact cells. J Biol Chem. 1986 Apr 5;261(10):4766-74.  [Content Brief]

  [5]. Ogier-Denis E, et al. Dual effect of Deoxymannojirimycin on the mannose uptake and on the N-glycan processing of the human colon cancer cell line HT-29. J Biol Chem. 1990 Apr 5;265(10):5366-9.  [Content Brief]

  [6]. F Vallee, et al. Structural Basis for Catalysis and Inhibition of N-glycan Processing Class I Alpha 1,2-mannosidases. J Biol Chem. 2000 Dec 29;275(52):41287-98.  [Content Brief]