2. 天然产物
  3. 植物 苯丙素类
  4. 胡椒科 木脂素
  5. 荜澄茄
  6. Dihydrocubebin

Dihydrocubebin  (Synonyms: (-)-Dihydrocubebin)

目录号: HY-N10421
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摩尔计算器

Dihydrocubebin 是一种从 Piper cubeba 中分离出来的化合物，是一种有效的、选择性的细胞色素 P450 3A4 (CYP3A4) 抑制剂。

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Dihydrocubebin Chemical Structure

Dihydrocubebin Chemical Structure

CAS No. : 24563-03-9

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Dihydrocubebin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dihydrocubebin is a compound isolated from Piper cubeba as potent and selective inhibitors against cytochrome P450 3A4 (CYP3A4)[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BC IC50
> 5 μg/mL
Compound: dihydrocubebin
Cytotoxicity against human BC cells by colorimetric method
Cytotoxicity against human BC cells by colorimetric method
[PMID: 16038539]
KB IC50
> 5 μg/mL
Compound: dihydrocubebin
Cytotoxicity against human KB cells by colorimetric method
Cytotoxicity against human KB cells by colorimetric method
[PMID: 16038539]
MCF7 IC50
89.4 μM
Compound: 9
Cytotoxicity against human MCF7 cells assessed as [3H]-hypoxanthine incorporation after 48 hrs
Cytotoxicity against human MCF7 cells assessed as [3H]-hypoxanthine incorporation after 48 hrs
[PMID: 20954722]
NCI-H187 IC50
> 5 μg/mL
Compound: dihydrocubebin
Cytotoxicity against human NCI-H187 cells by colorimetric method
Cytotoxicity against human NCI-H187 cells by colorimetric method
[PMID: 16038539]
Vero IC50
83.8 μM
Compound: 9
Cytotoxicity against african green monkey Vero cells assessed as [3H]-hypoxanthine incorporation after 48 hrs
Cytotoxicity against african green monkey Vero cells assessed as [3H]-hypoxanthine incorporation after 48 hrs
[PMID: 20954722]
分子量

358.39

Formula

C20H22O6
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Dihydrocubebin 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dihydrocubebin24563-03-9(-)-DihydrocubebinOthersPiper cubebaCYP3A4Inhibitorinhibitorinhibit

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