2. MAPK/ERK Pathway Cell Cycle/DNA Damage Apoptosis
  3. MNK Eukaryotic Initiation Factor (eIF) Apoptosis
  4. EB1

EB1 是 MNK 激酶的抑制剂，IC50 分别为 0.69 μM (MNK1) 和 9.4 μM (MNK2)。EB1 选择性地抑制癌细胞的生长，不抑制正常细胞的生长。EB1 还增加细胞凋亡，抑制 eIF4E 磷酸化。

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EB1 Chemical Structure

EB1 Chemical Structure

CAS No. : 42951-68-8

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规格 价格 是否有货 数量
1 mg ￥530
In-stock
5 mg ￥1250
In-stock
10 mg ￥1860
In-stock
25 mg ￥3160
In-stock
50 mg ￥4600
In-stock
100 mg 现货 询价
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

EB1 相关抗体

Top Publications Citing Use of Products

查看 MNK 亚型特异性产品:

查看所有亚型
MNK1 MNK2 MNK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EB1 is the inhibitor of kinases MNK with IC50s of 0.69 μM (MNK1) and 9.4 μM (MNK2). EB1 selectively inhibits the growth of cancer cells, but not normal cells. EB1 also increases cell apoptosis and suppresses eIF4E phosphorylation[1][2].

IC50 & Target[1]

MNK1

0.69 μM (IC50)

MNK2

9.4 μM (IC50)

eIF4E

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
IMR-90 GI50
> 40 μM
Compound: 6b; EB1
Cytotoxicity against human IMR-90 cells assessed as reduction in cell viability measured after 72 hrs by crystal violet staining based assay
Cytotoxicity against human IMR-90 cells assessed as reduction in cell viability measured after 72 hrs by crystal violet staining based assay
[PMID: 35417652]
MCF7 GI50
8.46 μM
Compound: 6b; EB1
Growth inhibition of human MCF7 cells measured after 72 hrs by crystal violet staining based assay
Growth inhibition of human MCF7 cells measured after 72 hrs by crystal violet staining based assay
[PMID: 35417652]
MDA-MB-231 GI50
15.08 μM
Compound: 6b; EB1
Growth inhibition of human MDA-MB-231 cells measured after 72 hrs by crystal violet staining based assay
Growth inhibition of human MDA-MB-231 cells measured after 72 hrs by crystal violet staining based assay
[PMID: 35417652]
MDA-MB-468 GI50
14.46 μM
Compound: 6b; EB1
Growth inhibition of human MDA-MB-468 cells measured after 72 hrs by crystal violet staining based assay
Growth inhibition of human MDA-MB-468 cells measured after 72 hrs by crystal violet staining based assay
[PMID: 35417652]
体外研究
(In Vitro)

EB1（1.3-40 μM；24 小时）剂量依赖性地抑制 eIF4E 的磷酸化[1]。
EB1（2.5-40 μM；72 小时）对肿瘤细胞显示出剂量依赖性细胞毒性，并诱导细胞凋亡[1]。
EB1（5 μM、10 μM 和 20 μM；24 小时）直接作用于 MNK 激酶，而不会干扰激活上游信号，例如 p38 的激活 (p-p38) 及其下游效应子 HSP27 的磷酸化[1]。
EB1 (compound 14) 抑制癌细胞 HepG2 和 MCF-7 的 IC50 分别为 0.74 μM 和 5.18 μM[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EB1 相关抗体:

Western Blot Analysis[1]

Cell Line: MDA-MB-231, MDA-MB-468, MCF7, and IMR90 cells
Concentration: 1.3 μM, 2.5 μM, 5 μM, 10 μM, 20 μM, 40 μM
Incubation Time: 24 hours
Result: Blocked the phosphorylation of eIF4E in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: MDA-MB-231, MDA-MB-468, MCF7, and IMR90 cells
Concentration: 2.5 μM, 5 μM, 10 μM, 20 μM, 40 μM
Incubation Time: 72 hours
Result: Increased the percentage of apoptosis cells among tumor cells.
分子量

286.33

Formula

C18H14N4
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 8.33 mg/mL (29.09 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.4925 mL 17.4624 mL 34.9247 mL
5 mM 0.6985 mL 3.4925 mL 6.9849 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

EB1 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4925 mL 17.4624 mL 34.9247 mL 87.3118 mL
5 mM 0.6985 mL 3.4925 mL 6.9849 mL 17.4624 mL
10 mM 0.3492 mL 1.7462 mL 3.4925 mL 8.7312 mL
15 mM 0.2328 mL 1.1642 mL 2.3283 mL 5.8208 mL
20 mM 0.1746 mL 0.8731 mL 1.7462 mL 4.3656 mL
25 mM 0.1397 mL 0.6985 mL 1.3970 mL 3.4925 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EB142951-68-8EB 1EB-1MNKEukaryotic Initiation Factor (eIF)ApoptosisMitogen activated protein kinase interacting kinaseMAP kinase interacting kinaseMAPK interacting kinaseInhibitorinhibitorinhibit

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