2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. Fexofenadine

Fexofenadine  (Synonyms: MDL-16455; Terfenadine carboxylate)

目录号: HY-B0801 纯度: 99.84%
COA 产品使用指南

摩尔计算器

Fexofenadine (MDL-16455) 是一种具有口服活性和非镇静性的 H1 受体拮抗剂。Fexofenadine 可用于过敏性鼻炎和慢性特发性荨麻疹的研究。

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Fexofenadine Chemical Structure

Fexofenadine Chemical Structure

CAS No. : 83799-24-0

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5 mg ￥460
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10 mg ￥650
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50 mg ￥1300
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100 mg ￥2100
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Customer Review

Other Forms of Fexofenadine:

Fexofenadine 相关抗体

Top Publications Citing Use of Products

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Fexofenadine (MDL-16455) is an orally active and nonsedative H1 receptor antagonist. Fexofenadine can be used in allergic rhinitis and chronic idiopathic urticarial research[1][2][3].

IC50 & Target[1]

H1 Receptor

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO-K1 IC50
78 nM
Compound: Fexofenadine
Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting
Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting
[PMID: 21470866]
CHO-K1 IC50
78 nM
Compound: 37
Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting
Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells by scintillation counting
10.1016/j.bmcl.2009.03.124
HEK293 IC50
23 μM
Compound: figure 2, R2C2
Inhibition of human Erg expressed in HEK293 cells assessed as rubidium efflux after 4 hrs by atomic absorbance spectrometric analysis
Inhibition of human Erg expressed in HEK293 cells assessed as rubidium efflux after 4 hrs by atomic absorbance spectrometric analysis
[PMID: 22542010]
HEK293 IC50
23 μM
Compound: 42, Fexofenadine
Inhibition of human ERG potassium channel in HEK293 cells by patch clamp assay
Inhibition of human ERG potassium channel in HEK293 cells by patch clamp assay
[PMID: 16931010]
HEK293 IC50
65 μM
Compound: Fexofenadine
Inhibition of human ERG expressed in HEK293 cells by whole cell patch clamp method
Inhibition of human ERG expressed in HEK293 cells by whole cell patch clamp method
[PMID: 19260734]
L929 IC50
> 100 nM
Compound: rac-2
Inhibition of human ERG in L929 cells by whole cell patch-clamp assay
Inhibition of human ERG in L929 cells by whole cell patch-clamp assay
[PMID: 19660947]
L929 IC50
> 100 μM
Compound: rac-2
Inhibition of human ERG in L929 cells at 10 uM by whole cell patch-clamp assay
Inhibition of human ERG in L929 cells at 10 uM by whole cell patch-clamp assay
[PMID: 19660947]
体外研究
(In Vitro)

Fexofenadine (1-100 µM; 1 h) inhibits the expression of IL-6 protein in nasal fibroblasts in a dose-dependent manner[2].
Fexofenadine (1-100 µM; 1 h) blocks phosphorylated p38 activation in histamine-induced nasal fibroblasts, but shows no effect on either pERK or pJNK[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Fexofenadine 相关抗体:

Western Blot Analysis[2]

Cell Line: Nasal fibroblasts
Concentration: 100 μM
Incubation Time: 1 hour
Result: Blocked pp38 activation in histamine-induced nasal fibroblasts, showed histamine-induced IL-6 production mediated by the p38 pathway.
体内研究
(In Vivo)

Fexofenadine hydrochloride (oral administration; 5-20 mg/kg; once daily; 3 w) suppresses both eosinophilia and systemic anaphylaxis in C57BL/6 mice infected with T. spiralis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice infected with Trichinella spiralis[1]
Dosage: 5, 10 and 20 mg/kg
Administration: Oral administration; 5, 10 and 20 mg/kg; once daily; 3 weeks
Result: Inhibited eosinophilia in a dose-dependent manner.
Suppressed the decrease in rectal temperature (p<0.01), a marker for systemic anaphylaxis.
Clinical Trial
分子量

501.66

Formula

C32H39NO4
CAS 号
性状

固体

颜色

Off-white to light yellow

中文名称

非索芬那定
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 10 mg/mL (19.93 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9934 mL 9.9669 mL 19.9338 mL
5 mM 0.3987 mL 1.9934 mL 3.9868 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.84%

COA (195 KB) HNMR (214 KB) LCMS (84 KB)

产品使用指南 (1538 KB)
参考文献

Fexofenadine 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9934 mL 9.9669 mL 19.9338 mL 49.8345 mL
5 mM 0.3987 mL 1.9934 mL 3.9868 mL 9.9669 mL
10 mM 0.1993 mL 0.9967 mL 1.9934 mL 4.9835 mL
15 mM 0.1329 mL 0.6645 mL 1.3289 mL 3.3223 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fexofenadine83799-24-0MDL-16455 Terfenadine carboxylate非索芬那定MDL16455MDL 16455Histamine Receptorallergic rhinitischronic idiopathic urticarialnasal fibroblastsInhibitorinhibitorinhibit

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