2. Apoptosis
  3. Apoptosis
  4. Garcinone E

Garcinone E 是一种天然的黄酮，存在于山竹果果皮中。Garcinone E 可诱导细胞凋亡 (apoptosis) 以及抑制癌细胞迁移。Garcinone-E 对不同的人类癌细胞系具有抗癌作用，包括结直肠癌、乳腺癌和肝细胞癌等。

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Garcinone E Chemical Structure

Garcinone E Chemical Structure

CAS No. : 112649-21-5

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规格 价格 是否有货 数量
1 mg ￥3700
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Garcinone E 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Garcinone E is a natural xanthone found in the rind of the mangosteen fruit. Garcinone E induces apoptosis and inhibits cancer cell migration. Garcinone E has anticancer effects on different human cancer cell lines, including colorectal, breast, and hepatocellular carcinomas[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HL-60 IC50
15 μM
Compound: 5
Cytotoxicity against human HL60 cells assessed as cell viability after 72 hrs by Trypan blue exclusion test
Cytotoxicity against human HL60 cells assessed as cell viability after 72 hrs by Trypan blue exclusion test
[PMID: 12932141]
MCF7 IC50
1.5 μg/mL
Compound: 8
Cytotoxicity against human MCF7 cells assessed as [3H]hypoxanthin incorporation after 24 to 72 hrs
Cytotoxicity against human MCF7 cells assessed as [3H]hypoxanthin incorporation after 24 to 72 hrs
[PMID: 19296616]
分子量

464.55

Formula

C28H32O6
CAS 号
性状

固体

颜色

Light yellow to yellow

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料
参考文献

Garcinone E 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Garcinone E112649-21-5Apoptosisxanthonemigrationapoptosisanticancercolorectalbreasthepatocellular carcinomaInhibitorinhibitorinhibit

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