ACTR1A - actin related protein 1A Gene

中文名称：肌动蛋白相关蛋白 1A

种属: Homo sapiens

同用名: ARP1; Arp1A; CTRN1

关于 ACTR1A

功能概要

该基因编码 dynactin 的一个 42.6 kD 亚基，dynactin 是一种大分子复合物，由 10-11 个亚基组成，大小从 22 到 150 kD 不等。 Dynactin 与微管和细胞质动力蛋白结合。它参与多种细胞功能，包括内质网到高尔基体的转运、溶酶体和核内体的向心运动、纺锤体形成、染色体运动、核定位和轴突发生。该亚基在每个 dynactin 分子中有 8-13 个拷贝，是 dynactin 复合物中最丰富的分子。它是一种肌动蛋白相关蛋白，在氨基酸水平上与常规肌动蛋白约有 60% 相同。[RefSeq 提供，2008 年 7 月]

This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. [provided by RefSeq, Jul 2008]