2. Gene
  3. STX6 - syntaxin 6 Gene

STX6 - syntaxin 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：突触融合蛋白 6

种属: Homo sapiens

基因 ID: 10228 | 基因类型: protein coding

关于 STX6

Cytogenetic location: 1q25.3 Genomic coordinates (GRCh38): 1:180,972,725-181,022,870 (from NCBI)

This gene has 4 transcripts (splice variants), 206 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 10.0), esophagus (RPKM 7.6) and 24 other tissues.

功能概要

启用 syntaxin 绑定活动。参与多个过程，包括高尔基带形成；逆行运输，内体到高尔基体；和囊泡融合。作用于内吞循环的上游或内。位于多种细胞成分中，包括早期内体；细胞质的核周区；和跨高尔基网络。 SNARE 复合体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables syntaxin binding activity. Involved in several processes, including Golgi ribbon formation; retrograde transport, endosome to Golgi; and vesicle fusion. Acts upstream of or within endocytic recycling. Located in several cellular components, including early endosome; perinuclear region of cytoplasm; and trans-Golgi network. Part of SNARE complex. [provided by Alliance of Genome Resources, Apr 2022]

STX6 基因产物(2)

mRNA Protein Name
NM_001286210.2 NP_001273139.1 syntaxin-6 isoform 2
NM_005819.6 NP_005810.1 syntaxin-6 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11384996 GOA
enables syntaxin binding IPI
IPI: 通过物理相互作用推断
16154903 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within endocytic recycling IMP
IMP: 通过突变表型推断
25799061 GOA
involved in endocytic recycling IMP
IMP: 通过突变表型推断
23677696 GOA
involved in regulation of protein localization IMP
IMP: 通过突变表型推断
16154903 GOA
involved in retrograde transport, endosome to Golgi IMP
IMP: 通过突变表型推断
19224922 GOA
involved in vesicle fusion IPI
IPI: 通过物理相互作用推断
10506127 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
19224922 GOA
part of SNARE complex IDA
IDA: 通过直接分析推断
19620288 GOA
located in early endosome IDA
IDA: 通过直接分析推断
10506127 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
10506127 GOA
located in trans-Golgi network IDA
IDA: 通过直接分析推断
16154903 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

STX6 蛋白结构

Syntaxin-6_N

Syntaxin-6_N: Syntaxin 6, N-terminal (5 - 103)

SNARE

SNARE: SNARE domain (168 - 228)

  • 0
  • 100
  • 200
  • 255 a.a.
蛋白主名 其他名称

syntaxin-6

重组 STX6 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71032 Syntaxin-6 Protein, Human O43752 (S2-Q234) ≥95%

关联疾病

疾病名称 别名
Cerebral Dysgenesis, Neuropathy, Ichthyosis, And Palmoplantar Keratoderma Syndrome

Cednik Syndrome

CEDNIK

Cerebral Dysgenesis, Neuropathy, Ichthyosis And Keratoderma Syndrome

Cerebral Dysgenesis, Neuropathy, Ichthyosis, And Palmoplantar Keratoderma Syndro

Cerebral Dysgenesis-Neuropathy-Ichthyosis-Palmoplantar Keratoderma Syndrome

Cerebral Dysgenesis-Neuropathy-Ichthyosis-Keratoderma Syndrome

Cerebral Dysgenesis, Neuropathy, Ichthyosis, And Palmoplantar Keratoderma

Neurocutaneous Syndromes
Pontocerebellar Hypoplasia, Type 2e

Pontocerebellar Hypoplasia Type 2

Pontocerebellar Hypoplasia Type 2e

Pch2

PCH2E

Progressive Microcephaly From Birth Extrapyramidal Dyskinesia Chorea Epilepsy

Pontocerebellar Hypoplasia 2e

Pcca2

Progressive Cerebello-Cerebral Atrophy Type 2

Doid:0112328

Hypoplasia, Pontocerebellar, Type 2e

Pontocerebellar Hypoplasia, Type 2d

Pontocerebellar Hypoplasia Type 2a
Supranuclear Palsy, Progressive, 1

Progressive Supranuclear Palsy

Steele-Richardson-Olszewski Syndrome

Supranuclear Palsy, Progressive

Progressive Supranuclear Ophthalmoplegia

Psp

PSNP1

Familial Progressive Supranuclear Palsy

Richardson'S Syndrome

Psp Syndrome

Progressive Supranuclear Palsy 1

Supranuclear Palsy Progressive

Ophthalmoplegia, Supranuclear, Progressive

Steele-Richardson-Olszewksi Syndrome
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13986 STX6 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta STX6 VGNC VGNC:78046
Felis catus STX6 VGNC VGNC:65816
Mus musculus STX6 MGD MGI:1926235
Rattus norvegicus STX6 RGD RGD:61915
Bos taurus STX6 VGNC VGNC:35442
Canis familiaris STX6 VGNC VGNC:55762
Others STX6 NCBI
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