PAK4 - p21 (RAC1) activated kinase 4 Gene

中文名称：p21 (RAC1) 激活激酶 4

种属: Homo sapiens

关于 PAK4

功能概要

PAK 蛋白是丝氨酸/苏氨酸 p21 激活激酶家族，包括 PAK1、PAK2、PAK3 和 PAK4。 PAK 蛋白是将 Rho GTP 酶与细胞骨架重组和核信号联系起来的关键效应物。它们作为小 GTP 结合蛋白 Cdc42 和 Rac 的靶标，并参与广泛的生物活动。 PAK4 与 GTP 结合形式的 Cdc42Hs 特异性相互作用，并弱激活 MAP 激酶的 JNK 家族。 PAK4 是丝状伪足形成的介质，可能在肌动蛋白细胞骨架的重组中发挥作用。已经为该基因发现了编码不同亚型的多个选择性剪接的转录物变体。[RefSeq 提供，2008 年 7 月]

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to Cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin Cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]