2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. PAK LIM Kinase (LIMK) Apoptosis Reactive Oxygen Species
  4. PAK4-IN-5

PAK4-IN-5 (Compound 12i) 是一种 PAK4 抑制剂 (IC50: PAK4 为 7.68 nM，PAK1 为 1872.01 nM)。PAK4-IN-5 通过多种相互作用稳定地与 PAK4 结合。PAK4-IN-5 通过抑制 PAK4 和 LIMK1 的磷酸化来抑制 MDA-MB-231 细胞的增殖和迁移潜力。PAK4-IN-5 将细胞周期停滞在 G0/G1 期，诱导细胞凋亡 (Apoptosis) 和活性氧产生。LD50：小鼠 >500 mg/kg (口服)。

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PAK4-IN-5 Chemical Structure

PAK4-IN-5 Chemical Structure

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Customer Review

PAK4-IN-5 相关抗体

Top Publications Citing Use of Products

查看 PAK 亚型特异性产品:

查看所有亚型
PAK1 PAK2 PAK3 PAK4 PAK5 PAK6

查看 LIM Kinase (LIMK) 亚型特异性产品:

查看所有亚型
LIMK1 LIMK2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PAK4-IN-5 (Compound 12i) is a PAK4 inhibitor (IC50: 7.68 nM for PAK4, 1872.01 nM for PAK1). PAK4-IN-5 binds to PAK4 stably via multiple interactions. PAK4-IN-5 inhibits the proliferation and the migratory potential of MDA-MB-231 cells by inhibiting the phosphorylation of PAK4 and LIMK1. PAK4-IN-5 arrests cell cycle in the G0/G1 phase, induces apoptosis and ROS production. LD50: >500 mg/kg for mice (p.o.)[1].

IC50 & Target[1]

PAK4

7.68 nM (IC50)

PAK1

1872.01 nM (IC50)

体外研究
(In Vitro)

PAK4-IN-5 抑制细胞增殖，IC50分别为 1.87 μM (A-549)、1.56 μM (NCI-H1975)、1.21 μM (MDA-MB-231)、2.33 μM (SK-BR-3)、28.68 μM (Beas-2B)、26.68 μM (MCF-10A)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PAK4-IN-5 相关抗体:
分子量

522.04

Formula

C31H28ClN5O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PAK4-IN-5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PAK4-IN-5PAKLIM Kinase (LIMK)ApoptosisReactive Oxygen Speciesp21 activated kinasesLIMKsMDA-MB-231breast cancerInhibitorinhibitorinhibit

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