B3GNT3 - UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 Gene

中文名称：UDP-GlcNAc:betaGal beta-1,3-N-乙酰氨基葡萄糖转移酶 3

种属: Homo sapiens

同用名: TMEM3; B3GN-T3; B3GNT-3; HP10328; B3GAL-T8; beta3Gn-T3

关于 B3GNT3

功能概要

该基因编码 beta-1,3-N-乙酰氨基葡萄糖转移酶家族的成员。这种酶是一种 II 型跨膜蛋白，包含一个未被切割的信号锚。它更倾向于乳糖-N-四糖和乳糖-N-新四糖的底物，并参与聚-N-乙酰基乳糖胺链的生物合成和二聚唾液酸 Lewis a 骨架结构的生物合成。它在 L-选择素配体生物合成、淋巴细胞归巢和淋巴细胞运输中起主导作用。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This Enzyme is a type II transmembrane protein and contains a signal anchor that is not cleaved. It prefers the substrates of lacto-N-tetraose and lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains and the biosynthesis of the backbone structure of dimeric sialyl Lewis a. It plays dominant roles in L-selectin ligand biosynthesis, lymphocyte homing and lymphocyte trafficking. [provided by RefSeq, Jul 2008]