ANAPC10 - anaphase promoting complex subunit 10 Gene

中文名称：后期促进复合亚基 10

种属: Homo sapiens

同用名: DOC1; APC10

关于 ANAPC10

功能概要

ANAPC10 是后期促进复合物 (APC) 或环状体的核心亚基，环状体是一种泛素蛋白连接酶，对于细胞周期的进展至关重要。 APC 通过泛素化后期抑制剂 securin (PTTG1; MIM 604147) 启动姐妹染色单体分离，并通过泛素化细胞周期蛋白 B (CCNB1; MIM 123836) 激活细胞周期蛋白依赖性激酶-1 (CDK1; MIM 116940) 的亚基来触发退出有丝分裂。 Wendt 等人总结，2001 [PubMed 11524682]) 。[OMIM 提供，2011 年 2 月]

ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein Ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by OMIM, Feb 2011]