PPIE - peptidylprolyl isomerase E Gene

中文名称：肽基脯氨酰异构酶 E

种属: Homo sapiens

同用名: CYP33; CYP-33

关于 PPIE

功能概要

该基因编码的蛋白质是肽基-脯氨酰顺反异构酶 (PPIase) 家族的成员。 PPIases 催化寡肽中脯氨酸亚胺肽键的顺反异构化，加速蛋白质的折叠。该蛋白质包含一个高度保守的亲环蛋白 (CYP) 结构域以及一个 RNA 结合结构域。它被证明具有 PPIase 和蛋白质折叠活性，并且还具有 RNA 结合活性。可变剪接导致多个转录本变体。已经确定了一个相关的假基因，它也位于 1 号染色体上。[RefSeq 提供，2010 年 8 月]

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved Cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified. [provided by RefSeq, Aug 2010]