CENPC - centromere protein C Gene

中文名称：着丝粒蛋白 C

种属: Homo sapiens

同用名: MIF2; hcp-4; CENP-C; CENPC1

基因 ID: 1060 | 基因类型: protein coding

关于 CENPC

Cytogenetic location: 4q13.2 Genomic coordinates (GRCh38): 4:67,468,762-67,545,503 (from NCBI)

This gene has 7 transcripts (splice variants) and 117 orthologues. Ubiquitous expression in bone marrow (RPKM 7.9), testis (RPKM 4.6) and 25 other tissues.

功能概要

着丝粒蛋白 C 1 是一种着丝粒自身抗原，是内着丝粒板的组成部分。这种蛋白质是维持适当的着丝粒大小和及时过渡到后期所必需的。假定的假基因存在于 12 号染色体上。[RefSeq 提供，2008 年 7 月]

Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. [provided by RefSeq, Jul 2008]

CENPC 基因产物(2)

mRNA	Protein	Name
NM_001362481.2	NP_001349410.1	centromere protein C isoform 2
NM_001812.4	NP_001803.2	centromere protein C isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	19503796	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	19503796	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in chromosome segregation	IMP IMP: 通过突变表型推断	21529714	GOA
involved in kinetochore assembly	IMP IMP: 通过突变表型推断	21529714	GOA
involved in mitotic cell cycle	IMP IMP: 通过突变表型推断	21529714	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in condensed chromosome, centromeric region	IDA IDA: 通过直接分析推断	11682612	GOA
part of inner kinetochore	IPI IPI: 通过物理相互作用推断	36085283	GOA
located in kinetochore	IDA IDA: 通过直接分析推断	21529714	GOA
located in pericentric heterochromatin	IDA IDA: 通过直接分析推断	21529714	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

centromere protein C

CENP-C 1

CENPC 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	CENPC	Q03188	CENPA	Homo sapiens	P49450	BiFC	19503796
Intra	CENPC	Q03188	CENPA	Homo sapiens	P49450	Anti Tag CoIP	19503796
Intra	CENPC	Q03188	DSN1	Homo sapiens	Q9H410	Anti Tag CoIP	33961781
Intra	CENPC	Q03188	DSN1	Homo sapiens	Q9H410	Anti Tag CoIP	28514442
Intra	CENPC	Q03188	PMF1	Homo sapiens	Q6P1K2	Anti Tag CoIP	33961781
Intra	CENPC	Q03188	H1-5	Homo sapiens	P16401	Crosslink	30021884
Intra	CENPC	Q03188	PMF1	Homo sapiens	Q6P1K2	Anti Tag CoIP	28514442
Intra	CENPC	Q03188	NDC80	Homo sapiens	O14777	Anti Tag CoIP	33961781
Intra	CENPC	Q03188	MIS12	Homo sapiens	Q9H081	Anti Tag CoIP	33961781
Intra	CENPC	Q03188	ACTA2	Homo sapiens	P62736	Anti Tag CoIP	33961781
Intra	CENPC	Q03188	NDC80	Homo sapiens	O14777	Anti Tag CoIP	28514442
Intra	CENPC	Q03188	MIS12	Homo sapiens	Q9H081	Anti Tag CoIP	28514442
Intra	CENPC	Q03188	NUF2	Homo sapiens	Q9BZD4	Anti Tag CoIP	33961781
Intra	CENPC	Q03188	ACTA2	Homo sapiens	P62736	Anti Tag CoIP	28514442
Intra	CENPC	Q03188	NUF2	Homo sapiens	Q9BZD4	Anti Tag CoIP	28514442

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hyperinsulinemic Hypoglycemia, Familial, 5

Hyperinsulinism Due To Insr Deficiency	HHF5
Familial Hyperinsulinemic Hypoglycemia 5	Hyperinsulinemic Hypoglycemia Due To Insr Deficiency
Hyperinsulinemic Hypoglycemia Due To Insulin Receptor Deficiency	Congenital Hyperinsulinism
Persistent Hyperinsulinemic Hypoglycemia Of Infancy	Phhi
Hyperinsulinemic Hypoglycemia Familial 5

Crest Syndrome

Cowden Syndrome 1

Bannayan-Riley-Ruvalcaba Syndrome	Pten Hamartoma Tumor Syndrome
Lhermitte-Duclos Disease	Bannayan-Zonana Syndrome
Phts	Riley-Smith Syndrome
Bzs	Ruvalcaba-Myhre-Smith Syndrome
Multiple Hamartoma Syndrome	Rmss
Brrs	Dysplastic Gangliocytoma Of The Cerebellum
CWS1	Cs
Cd	Mham
Pten Hamartoma Tumor Syndrome With Granular Cell Tumor	Macrocephaly Multiple Lipomas And Hemangiomata
Bannayan-Ruvalcaba-Riley Syndrome	Myhre-Riley-Smith Syndrome
LDD	Cerebelloparenchymal Disorder Vi
Hamartoma Syndrome, Multiple	Bbrs
Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata	Macrocephaly, Multiple Lipomas, And Hemangiomata
Macrocephaly Pseudopapilledema And Multiple Hemangiomas	Ruvalcaba -Myhre-Smith Syndrome
Ruvalcaba-Myhre Syndrome	Cowden Disease
Macrocephaly Pseudopapilledema And Multiple Hemangiomata	Cerebellar Granule Cell Hypertrophy And Megalencephaly
Cpd6	Pten Hamartoma Tumor Syndromes
Cowden Syndrome, Type 1

Limited Scleroderma

Limited Cutaneous Systemic Sclerosis	Limited Systemic Sclerosis
Systemic Sclerosis Sine Scleroderma	Crest Syndrome
Limited Cutaneous Systemic Scleroderma	Scleroderma, Limited
Systemic Sclerosis, Limited	Progressive Systemic Sclerosis Sine Scleroderma
Scleroderma, Sine	Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome
Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome

Dyskinesia Of Esophagus

Esophageal Motility Disorders	Dyskinesia Of Oesophagus
Esophageal Dysmotility	Esophageal Motility Disorder
Oesophageal Dysmotility	Oesophageal Motor Disorder
Esophageal Spasm

Glanders

Farcy Pipes	Infection Due To Pseudomonas Mallei
Burkholderia Mallei	Burkholderia Mallei Infection
Equina	Equine Glanders
Farcy	Farcy Buds
Farcy Cords	Infection Due To Actinobacillus Mallei
Infection Due To Malleomyces Mallei	Maliasmus
Malleus	Farce
Actinobacillosis	Actinobacillus Infection

Cowden Syndrome

Cowden Disease	Multiple Hamartoma Syndrome
Cowden'S Disease	Lhermitte-Duclos Disease
Cd	Cs
Mham	Dysplastic Gangliocytoma Of Cerebellum
Cowden'S Syndrome	Hamartoma Syndrome, Multiple

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02475	CENPC Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	CENPC	VGNC	VGNC:27174
Mus musculus	CENPC	MGD	MGI:99700
Canis familiaris	CENPC	VGNC	VGNC:39102
Rattus norvegicus	CENPC	RGD	RGD:1303061
Macaca mulatta	CENPC	VGNC	VGNC:71007
Felis catus	CENPC	VGNC	VGNC:60753

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4