UGT2A1 - UDP glucuronosyltransferase family 2 member A1 complex locus Gene

中文名称：UDP 葡萄糖醛酸转移酶家族 2 成员 A1 复合基因座

种属: Homo sapiens

同用名: UDPGT2A1

关于 UGT2A1

功能概要

该基因编码的蛋白质属于 UDP-糖基转移酶家族。这个蛋白质家族的成员在结合和随后消除潜在有毒的外源性化合物和内源性化合物中发挥作用。编码的酶在嗅觉神经上皮细胞中表达，嗅觉神经上皮细胞排列在后鼻腔内，并暴露于各种气味剂和空气传播的有毒化合物。因此，有人建议这种蛋白质参与从感觉上皮细胞中清除亲脂性气味分子。该基因与 UDP 葡萄糖醛酸转移酶 2A2 家族成员共享外显子结构，后者编码 N 末端不同的亚型。该基因的多态性可能与一些人在 SARS-CoV-2 感染期间报告的味觉和嗅觉丧失有关。[RefSeq 提供，2022 年 1 月]

The protein encoded by this gene belongs to the UDP-glycosyltransferase family. Members of this protein family play a role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The encoded Enzyme is expressed in the olfactory neuroepithelium, which lines the posterior nasal cavity and is exposed to a wide range of odorants and airborne toxic compounds. Hence, this protein has been suggested to be involved in clearing lipophilic odorant molecules from the sensory epithelium. This gene shares exon structure with the UDP glucuronosyltransferase 2A2 family member, which encodes N-terminally distinct isoforms. Polymorphisms in this gene may be associated with the loss of taste and smell that is reported by some individuals during SARS-CoV-2 Infection. [provided by RefSeq, Jan 2022]