ESM1 - endothelial cell specific molecule 1 Gene

中文名称：内皮细胞特异性分子 1

种属: Homo sapiens

同用名: endocan

基因 ID: 11082 | 基因类型: protein coding

关于 ESM1

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:54,977,867-54,985,593 (from NCBI)

This gene has 4 transcripts (splice variants) and 196 orthologues. Biased expression in thyroid (RPKM 12.6), kidney (RPKM 8.9) and 9 other tissues.

功能概要

该基因编码一种分泌蛋白，主要在人肺和肾组织的内皮细胞中表达。该基因的表达受细胞因子调节，表明它可能在内皮依赖性病理障碍中发挥作用。转录物包含多个聚腺苷酸化和 mRNA 不稳定信号。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2008 年 10 月]

This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

ESM1 基因产物(2)

mRNA	Protein	Name
NM_001135604.2	NP_001129076.1	endothelial cell-specific molecule 1 isoform b precursor
NM_007036.5	NP_008967.1	endothelial cell-specific molecule 1 isoform a precursor

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables hepatocyte growth factor receptor binding	IPI IPI: 通过物理相互作用推断	11590178	GOA
enables integrin binding	IPI IPI: 通过物理相互作用推断	11544294	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in angiogenesis	IEP IEP: 通过表达模式推断	11866539	GOA
involved in positive regulation of cell population proliferation	IDA IDA: 通过直接分析推断	11590178	GOA
involved in positive regulation of hepatocyte growth factor receptor signaling pathway	IDA IDA: 通过直接分析推断	11590178	GOA
involved in sprouting angiogenesis	IMP IMP: 通过突变表型推断	20616313	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ESM1 蛋白结构

IGFBP

0
100
184 a.a.

蛋白主名

其他名称

endothelial cell-specific molecule 1

ESM-1

ESM1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ESM1	Q9NQ30	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
种属内	ESM1	Q9NQ30	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
种属内	ESM1	Q9NQ30	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
种属内	ESM1	Q9NQ30	VGLL3	Homo sapiens	A8MV65-2	Y2H Prey Pooling	32296183
种属内	ESM1	Q9NQ30	VGLL3	Homo sapiens	A8MV65-2	Y2H Array	32296183
种属内	ESM1	Q9NQ30	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
种属内	ESM1	Q9NQ30	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
种属内	ESM1	Q9NQ30	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
种属内	ESM1	Q9NQ30	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
种属内	ESM1	Q9NQ30	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
种属内	ESM1	Q9NQ30	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
种属内	ESM1	Q9NQ30	WFS1	Homo sapiens	O76024	Y2H Array	32814053
种属内	ESM1	Q9NQ30	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
种属内	ESM1	Q9NQ30	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	32296183
种属内	ESM1	Q9NQ30	HOXA1	Homo sapiens	P49639	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ESM1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70151	ESM-1 Protein, Human (HEK293, His)	AAH11989.1/Q9NQ30-1 (W20-R184 )	≥95%
HY-P75219	ESM-1 Protein, Human (sf9, His)	Q9NQ30-1/NP_008967.1 (W20-R184)	≥95%

关联疾病

疾病名称

别名

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04526	ESM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	ESM1	VGNC	VGNC:40474
Bos taurus	ESM1	VGNC	VGNC:28602
Mus musculus	ESM1	MGD	MGI:1918940
Macaca mulatta	ESM1	VGNC	VGNC:72431
Rattus norvegicus	ESM1	RGD	RGD:71013
Felis catus	ESM1	VGNC	VGNC:61962
Others	ESM1	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ESM1 - endothelial cell specific molecule 1 Gene

关于 ESM1

功能概要

ESM1 基因产物(2)

ESM1 蛋白结构

ESM1 蛋白互作信息

重组 ESM1 蛋白

关联疾病

直系同源

热门区域

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ESM1 - endothelial cell specific molecule 1 Gene

关于 ESM1

功能概要

ESM1 基因产物(2)

ESM1 蛋白结构

ESM1 蛋白互作信息

重组 ESM1 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z