PTPMT1 - protein tyrosine phosphatase mitochondrial 1 Gene

中文名称：蛋白酪氨酸磷酸酶线粒体 1

种属: Homo sapiens

同用名: MOSP; PLIP; DUSP23; PNAS-129

基因 ID: 114971 | 基因类型: protein coding

关于 PTPMT1

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:47,565,599-47,573,461 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 173 orthologues and 30 paralogues. Ubiquitous expression in testis (RPKM 16.1), brain (RPKM 11.9) and 25 other tissues.

功能概要

预计可启用磷脂酰甘油磷酸酶活性和磷脂酰肌醇 4,5-二磷酸 5-磷酸酶活性。参与内在凋亡信号通路的调节。位于线粒体中。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable phosphatidylglycerophosphatase activity and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Involved in regulation of intrinsic apoptotic signaling pathway. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

PTPMT1 基因产物(2)

mRNA	Protein	Name
NM_001143984.2	NP_001137456.1	phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 isoform 2
NM_175732.3	NP_783859.1	phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	21516116	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in regulation of intrinsic apoptotic signaling pathway	IGI IGI: 通过遗传相互作用推断	24709986	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in mitochondrion	IDA IDA: 通过直接分析推断	38322995	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PTPMT1 蛋白结构

DSPc

0
100
201 a.a.

蛋白主名

其他名称

phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

NB4 apoptosis/differentiation related protein

PTPMT1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PTPMT1	Q8WUK0	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
种属内	PTPMT1	Q8WUK0	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
种属内	PTPMT1	Q8WUK0	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
种属内	PTPMT1	Q8WUK0	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
种属内	PTPMT1	Q8WUK0	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	25416956
种属内	PTPMT1	Q8WUK0	KRTAP10-9	Homo sapiens	P60411	Y2H Array	32296183
种属内	PTPMT1	Q8WUK0	KRTAP10-9	Homo sapiens	P60411	Y2H Prey Pooling	32296183
种属内	PTPMT1	Q8WUK0	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	32296183
种属内	PTPMT1	Q8WUK0	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
种属内	PTPMT1	Q8WUK0	KRTAP10-7	Homo sapiens	P60409	Y2H Array	32296183
种属内	PTPMT1	Q8WUK0	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Array	32296183
种属内	PTPMT1	Q8WUK0	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Prey Pooling	32296183
种属内	PTPMT1	Q8WUK0	RGS20	Homo sapiens	O76081-6	Y2H Prey Pooling	32296183
种属内	PTPMT1	Q8WUK0	RGS20	Homo sapiens	O76081-6	Validated Y2H	25416956
种属内	PTPMT1	Q8WUK0	RGS20	Homo sapiens	O76081-6	Y2H Array	32296183
种属内	PTPMT1	Q8WUK0	RGS20	Homo sapiens	O76081-6	Y2H Array	25416956
种属内	PTPMT1	Q8WUK0	KRTAP2-3	Homo sapiens	P0C7H8	Y2H Array	25416956
种属内	PTPMT1	Q8WUK0	KRTAP2-3	Homo sapiens	P0C7H8	Validated Y2H	25416956
种属内	PTPMT1	Q8WUK0	KRTAP9-3	Homo sapiens	Q9BYQ3	Y2H Array	32296183
种属内	PTPMT1	Q8WUK0	KRTAP9-3	Homo sapiens	Q9BYQ3	Y2H Prey Pooling	32296183
种属内	PTPMT1	Q8WUK0	KRTAP9-3	Homo sapiens	Q9BYQ3	Validated Y2H	32296183
种属内	PTPMT1	Q8WUK0	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Prey Pooling	32296183
种属内	PTPMT1	Q8WUK0	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Array	25416956
种属内	PTPMT1	Q8WUK0	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Array	32296183
种属内	PTPMT1	Q8WUK0	KRTAP9-2	Homo sapiens	Q9BYQ4	Validated Y2H	32296183
种属内	PTPMT1	Q8WUK0	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
种属内	PTPMT1	Q8WUK0	KRT34	Homo sapiens	O76011	Y2H Array	32296183
种属内	PTPMT1	Q8WUK0	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
种属内	PTPMT1	Q8WUK0	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
种属内	PTPMT1	Q8WUK0	KRTAP12-3	Homo sapiens	P60328	Y2H Prey Pooling	32296183
种属内	PTPMT1	Q8WUK0	KRTAP12-3	Homo sapiens	P60328	Y2H Array	32296183
种属内	PTPMT1	Q8WUK0	LCE2C	Homo sapiens	Q5TA81	Y2H Array	32296183
种属内	PTPMT1	Q8WUK0	LCE2C	Homo sapiens	Q5TA81	Y2H Prey Pooling	32296183
种属内	PTPMT1	Q8WUK0	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Prey Pooling	32296183
种属内	PTPMT1	Q8WUK0	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Array	32296183
种属内	PTPMT1	Q8WUK0	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
种属内	PTPMT1	Q8WUK0	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
种属内	PTPMT1	Q8WUK0	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
种属内	PTPMT1	Q8WUK0	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
种属内	PTPMT1	Q8WUK0	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	25416956
种属内	PTPMT1	Q8WUK0	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	32296183
种属内	PTPMT1	Q8WUK0	KRTAP5-9	Homo sapiens	P26371	Y2H Array	25416956
种属内	PTPMT1	Q8WUK0	KRTAP5-9	Homo sapiens	P26371	Y2H Array	32296183
种属内	PTPMT1	Q8WUK0	KRTAP5-9	Homo sapiens	P26371	Validated Y2H	25416956
种属内	PTPMT1	Q8WUK0	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	25416956
种属内	PTPMT1	Q8WUK0	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
种属内	PTPMT1	Q8WUK0	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
种属内	PTPMT1	Q8WUK0	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	25416956
种属内	PTPMT1	Q8WUK0	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
种属内	PTPMT1	Q8WUK0	MDFI	Homo sapiens	Q99750	Validated Y2H	25416956
种属内	PTPMT1	Q8WUK0	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
种属内	PTPMT1	Q8WUK0	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
种属内	PTPMT1	Q8WUK0	MDFI	Homo sapiens	Q99750	Y2H	21516116
种属内	PTPMT1	Q8WUK0	KRTAP4-12	Homo sapiens	Q9BQ66	Validated Y2H	32296183
种属内	PTPMT1	Q8WUK0	KRTAP4-12	Homo sapiens	Q9BQ66	Y2H Array	32296183
种属内	PTPMT1	Q8WUK0	KRTAP4-12	Homo sapiens	Q9BQ66	Y2H Prey Pooling	32296183
种属内	PTPMT1	Q8WUK0	MTUS2	Homo sapiens	Q5JR59	Validated Y2H	25416956
种属内	PTPMT1	Q8WUK0	GRN	Homo sapiens	P28799	Y2H Prey Pooling	32296183
种属内	PTPMT1	Q8WUK0	GRN	Homo sapiens	P28799	Y2H Array	32296183
种属内	PTPMT1	Q8WUK0	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
种属内	PTPMT1	Q8WUK0	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
种属内	PTPMT1	Q8WUK0	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
种属内	PTPMT1	Q8WUK0	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956
种属内	PTPMT1	Q8WUK0	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	25416956
种属内	PTPMT1	Q8WUK0	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
种属内	PTPMT1	Q8WUK0	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
种属内	PTPMT1	Q8WUK0	KRT31	Homo sapiens	Q15323	Validated Y2H	25416956
种属内	PTPMT1	Q8WUK0	KRTAP3-1	Homo sapiens	Q9BYR8	Validated Y2H	32296183
种属内	PTPMT1	Q8WUK0	KRTAP3-1	Homo sapiens	Q9BYR8	Y2H Prey Pooling	32296183
种属内	PTPMT1	Q8WUK0	KRTAP3-1	Homo sapiens	Q9BYR8	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PTPMT1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P76556	PTPMT1 Protein, Human (His)	Q8WUK0-1 (K28-T201)	≥95%

关联疾病

疾病名称

别名

Mitochondrial Complex Ii Deficiency

Isolated Mitochondrial Respiratory Chain Complex Ii Deficiency	Isolated Succinate-Coenzyme Q Reductase Deficiency
Isolated Succinate-Coq Reductase Deficiency	Isolated Succinate-Ubiquinone Reductase Deficiency
Mitochondrial Respiratory Chain Complex Ii Deficiency	Complex 2 Mitochondrial Respiratory Chain Deficiency
Succinate Coq Reductase Deficiency	Succinate Dehydrogenase Deficiency
Isolated Succinate Dehydrogenase Deficiency	Succinate-Coenzyme Q Reductase Deficiency

Barth Syndrome

3-Methylglutaconic Aciduria Type 2	BTHS
Cardioskeletal Myopathy With Neutropenia And Abnormal Mitochondria	Mga Type Ii
Mga2	Mgca2
Mga Type 2	3-Methylglutaconic Aciduria Type Ii
3-Methylglutaconic Aciduria, Type Ii	Mga, Type Ii
3-Methylglutaconicaciduria Type 2	3-Methylglutaconicaciduria Type Ii
Taz Defect	3 Methylglutaconic Aciduria, Type Ii
Dnajc19 Defect	Cardioskeletal Myopathy-Neutropenia Syndrome
X-Linked Cardioskeletal Myopathy And Neutropenia	3-Alpha-Methylglutaconic Aciduria Type 2
Agm2	Cardioskeletal Myopathy-Neutropenia
Invm	Left Ventricular Non-Compaction Isolated X-Linked
Non-Compaction Of Left Ventricular Myocardium Isolated X-Linked	Agammaglobulinemia 2, Autosomal Recessive

Myopathy, Centronuclear, X-Linked

X-Linked Myotubular Myopathy	Xlmtm
X-Linked Centronuclear Myopathy	Xlcnm
CNMX	Mtm1
Myotubular Myopathy, X-Linked	Mtmx
Myotubular Myopathy 1	Centronuclear Myopathy X-Linked
Myotubular Myopathy	Mtm
Cnm	Xmtm
Myotubular Myopathy Type 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-108547	Alexidine dihydrochloride		99.59%	否
HY-B1474	Alexidine	Inhibitor	/	否
HY-RS11414	PTPMT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	PTPMT1	VGNC	VGNC:45166
Rattus norvegicus	PTPMT1	RGD	RGD:1589783
Macaca mulatta	PTPMT1	VGNC	VGNC:110527
Bos taurus	PTPMT1	VGNC	VGNC:33528
Mus musculus	PTPMT1	MGD	MGI:1913711
Others	PTPMT1	NCBI

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