2. Gene
  3. DIS3L - DIS3 like exosome 3'-5' exoribonuclease Gene

DIS3L - DIS3 like exosome 3'-5' exoribonuclease Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：DIS3 样外泌体 3'-5' 核糖核酸外切酶

种属: Homo sapiens

同用名: DIS3L1

基因 ID: 115752 | 基因类型: protein coding

关于 DIS3L

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:66,293,309-66,333,898 (from NCBI)

This gene has 14 transcripts (splice variants), 196 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 7.4), testis (RPKM 7.4) and 25 other tissues.

功能概要

细胞质 RNA 外泌体复合物降解不稳定的 mRNA，并参与其他 mRNA 的定期更新。该基因编码的蛋白质含有 3'-5' 核糖核酸外切酶活性，是该复合物的催化成分。[RefSeq 提供，2016 年 5 月]

The cytoplasmic RNA exosome complex degrades unstable mRNAs and is involved in the regular turnover of Other mRNAs. The protein encoded by this gene contains 3'-5' exoribonuclease activity and is a catalytic component of this complex. [provided by RefSeq, May 2016]

DIS3L 基因产物(13)

mRNA Protein Name
NM_001143688.3 NP_001137160.1 DIS3-like exonuclease 1 isoform 1
NM_001323936.2 NP_001310865.1 DIS3-like exonuclease 1 isoform 2
NM_001323937.2 NP_001310866.1 DIS3-like exonuclease 1 isoform 5
NM_001323938.2 NP_001310867.1 DIS3-like exonuclease 1 isoform 3
NM_001323939.2 NP_001310868.1 DIS3-like exonuclease 1 isoform 3
NM_001323940.2 NP_001310869.1 DIS3-like exonuclease 1 isoform 4
NM_001323941.2 NP_001310870.1 DIS3-like exonuclease 1 isoform 3
NM_001323943.2 NP_001310872.1 DIS3-like exonuclease 1 isoform 4
NM_001323944.2 NP_001310873.1 DIS3-like exonuclease 1 isoform 6
NM_001323945.2 NP_001310874.1 DIS3-like exonuclease 1 isoform 2
NM_001323946.2 NP_001310875.1 DIS3-like exonuclease 1 isoform 3
NM_001323948.2 NP_001310877.1 DIS3-like exonuclease 1 isoform 7
NM_133375.5 NP_588616.1 DIS3-like exonuclease 1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3'-5'-RNA exonuclease activity IDA
IDA: 通过直接分析推断
20531389 GOA
enables 3'-5'-RNA exonuclease activity IMP
IMP: 通过突变表型推断
20531386 GOA
enables enzyme binding IPI
IPI: 通过物理相互作用推断
20531386 GOA
enables exoribonuclease II activity IDA
IDA: 通过直接分析推断
37602378 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20531386 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in RNA catabolic process IDA
IDA: 通过直接分析推断
20531386 GOA
involved in RNA processing IDA
IDA: 通过直接分析推断
20531386 GOA
involved in rRNA catabolic process IDA
IDA: 通过直接分析推断
20531389 GOA
involved in rRNA catabolic process IMP
IMP: 通过突变表型推断
20368444 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of cytoplasmic exosome (RNase complex) IDA
IDA: 通过直接分析推断
20531386 GOA
located in cytosol IDA
IDA: 通过直接分析推断
20531386 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DIS3L 蛋白结构

RNB

RNB: RNB domain (465 - 816)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1054 a.a.
蛋白主名 其他名称

DIS3-like exonuclease 1

DIS3 mitotic control homolog-like

DIS3L 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DIS3L Q8TF46 EXOSC3 Homo sapiens Q9NQT5
Anti Bait CoIP
20531386
种属内
DIS3L Q8TF46 EXOSC3 Homo sapiens Q9NQT5
Anti Tag CoIP
23756462
种属内
DIS3L Q8TF46 EXOSC3 Homo sapiens Q9NQT5
Anti Tag CoIP
33961781
种属内
DIS3L Q8TF46 EXOSC3 Homo sapiens Q9NQT5
Anti Tag CoIP
26496610
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Perlman Syndrome

Nephroblastomatosis, Fetal Ascites, Macrosomia And Wilms Tumor

PRLMNS

Renal Hamartomas, Nephroblastomatosis, And Fetal Gigantism

Nephroblastomatosis Fetal Ascites Macrosomia And Wilms Tumor

Nephroblastomatosis, Fetal Ascites, Macrosomia, And Wilms Tumor

Nephroblastomatosis - Fetal Ascites - Macrosomia - Wilms Tumor

Renal Hamartomas, Nephroblastomatosis And Fetal Gigantism

Nephroblastomatosis-Fetal Ascites-Macrosomia-Wilms Tumor Syndrome

Renal Hamartomas Nephroblastomatosis And Fetal Gigantism

Nephroblastoma

Fetal Macrosomia
Trichohepatoenteric Syndrome 1

Trichohepatoenteric Syndrome

Syndromic Diarrhea

Tricho-Hepato-Enteric Syndrome

Sd/The

Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome

THES1

Phenotypic Diarrhea

Thes

Phenotypic Diarrhea Of Infancy

Diarrhea, Syndromic

Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa

Intractable Diarrhea With Phenotypic Anomalies

Syndromatic Diarrhea

Fatal Infantile Diarrhea With Trichorrhexis Nodosa
Trichohepatoenteric Syndrome 2

THES2
Pontocerebellar Hypoplasia

Pch

Congenital Pontocerebellar Hypoplasia

Opch

Hypoplasia, Pontocerebellar

Pontoneocerebellar Hypoplasia

Nonsyndromic Pontocerebellar Hypoplasia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03779 DIS3L Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS03780 DIS3L2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus DIS3L MGD MGI:2143272
Bos taurus DIS3L VGNC VGNC:28073
Canis familiaris DIS3L VGNC VGNC:39963
Macaca mulatta DIS3L VGNC VGNC:71796
Rattus norvegicus DIS3L RGD RGD:1308959
Felis catus DIS3L VGNC VGNC:61500
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