CKMT1B - creatine kinase, mitochondrial 1B Gene

中文名称：肌酸激酶，线粒体 1B

种属: Homo sapiens

同用名: CKMT; CKMT1; UMTCK

关于 CKMT1B

功能概要

线粒体肌酸 (MtCK) 激酶负责将高能磷酸盐从线粒体转移到胞质载体肌酸。它属于肌酸激酶同工酶家族。它以两种同工酶形式存在，即肌节 MtCK 和普遍存在的 MtCK，由不同的基因编码。线粒体肌酸激酶以两种不同的寡聚形式存在：二聚体和八聚体，与完全二聚的胞质肌酸激酶同工酶形成对比。许多预后不良的恶性癌症都表现出普遍存在的线粒体肌酸激酶的过度表达；这可能与高能量转换和未能通过细胞凋亡消除癌细胞有关。普遍存在的线粒体肌酸激酶与肌节线粒体肌酸激酶的编码外显子具有 80% 的同源性。已鉴定出位于 15 号染色体上彼此靠近的两个基因，它们编码相同的线粒体肌酸激酶蛋白。[RefSeq 提供，2008 年 7 月]

Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate Cancer cells via Apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins. [provided by RefSeq, Jul 2008]