1. Gene
  2. Amh - anti-Mullerian hormone Gene

Amh - anti-Mullerian hormone Gene

种属: Mus musculus

同用名: MIS

基因 ID: 11705 | 基因类型: protein coding

关于 Amh

功能概要

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Homozygous knockout male mice develop female reproductive organs and are often sterile, while homozygous knockout female mice exhibit premature depletion of primordial follicles. [provided by RefSeq, Jul 2016]

Amh 基因产物(1)

mRNA Protein Name
NM_007445.3 NP_031471.2 muellerian-inhibiting factor precursor
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Leydig cell differentiation IMP
IMP: 通过突变表型推断
9435237 MGI
involved in negative regulation of ovarian follicle development IMP
IMP: 通过突变表型推断
11861535 MGI
involved in ovarian follicle development IMP
IMP: 通过突变表型推断
11606457 MGI
involved in sex determination IMP
IMP: 通过突变表型推断
7954809 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
15789443 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

muellerian-inhibiting factor

Mullerian inhibiting substance

anti-Muellerian hormone

muellerian-inhibiting substance

重组 Amh 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71712 Muellerian-inhibiting factor/AMH Protein, Mouse (P.pastoris, His) P27106 (450D-552C) ≥95%
HY-P72077 Muellerian-inhibiting factor/AMH Protein, Mouse P27106 (D450-C552) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Amh NCBI NCBI:268
Macaca fascicularis Amh NCBI NCBI:102144003
Macaca mulatta Amh NCBI NCBI:717539